LPP Antibody (8B3A11): sc-101434

LPP Antibody (8B3A11) is a mouse monoclonal IgG1 kappa light chain antibody that detects LPP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). LPP Antibody (8B3A11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LPP (8B3A11) antibody recognizes LIM-containing lipoma-preferred partner, which plays a crucial role in cellular processes by acting as a scaffolding protein that facilitates the assembly of signaling complexes at sites of cell adhesion, such as focal adhesions and cell-cell contacts. This localization is vital for maintaining cellular integrity and communication, as LPP helps regulate cytoskeletal dynamics and signal transduction pathways essential for cell migration and tissue development. LPP (8B3A11) monoclonal antibody targets a protein that can translocate to the nucleus, where LPP influences gene expression through transcriptional activation, further underscoring its importance in cellular function. The human LPP gene is located on chromosome 3q28 and preferentially translocates to the HMGIC gene in a specific subset of benign mesenchymal tumors called lipomas, highlighting its potential role in tumorigenesis.

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LPP Antibody (8B3A11) References:

1. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.  |  Petit, MM., et al. 2000. Mol Biol Cell. 11: 117-29. PMID: 10637295
2. Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23).  |  Dahéron, L., et al. 2001. Genes Chromosomes Cancer. 31: 382-9. PMID: 11433529
3. The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein.  |  Petit, MM., et al. 2003. J Biol Chem. 278: 2157-68. PMID: 12441356
4. The lipoma preferred partner LPP interacts with alpha-actinin.  |  Li, B., et al. 2003. J Cell Sci. 116: 1359-66. PMID: 12615977
5. LPP, a LIM protein highly expressed in smooth muscle.  |  Gorenne, I., et al. 2003. Am J Physiol Cell Physiol. 285: C674-85. PMID: 12760907
6. The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.  |  Petit, MM., et al. 2005. BMC Cell Biol. 6: 1. PMID: 15649318
7. LPP inhibits collective cell migration during lung cancer dissemination.  |  Kuriyama, S., et al. 2016. Oncogene. 35: 952-64. PMID: 26028032
8. Dataset: The Linked Personnel Panel (LPP).  |  Haylock, M. and Kampkötter, P. 2019. Data Brief. 27: 104824. PMID: 31828187
9. Lipoprotein Lpp regulates the mechanical properties of the E. coli cell envelope.  |  Mathelié-Guinlet, M., et al. 2020. Nat Commun. 11: 1789. PMID: 32286264
10. The P300, the LPP, context updating, and memory: What is the functional significance of the emotion-related late positive potential?  |  Fields, EC. 2023. Int J Psychophysiol. 192: 43-52. PMID: 37586592
11. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family.  |  Petit, MM., et al. 1996. Genomics. 36: 118-29. PMID: 8812423
12. The urethra (UPP, MUPP, instability, LPP).  |  Khullar, V. and Cardozo, L. 1998. Eur Urol. 34 Suppl 1: 20-2. PMID: 9705549

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LPP Antibody (8B3A11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-LPP Antibody (8B3A11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LPP Antibody (8B3A11) Specifications

Alternate Product Name: LPP

Product Clone Name: 8B3A11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: LPP

Epitope Species: human

Product Reactivity/Detection: LPP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for LPP Antibody (8B3A11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin