LPL Antibody (F-1): sc-373759

LPL Antibody (F-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects LPL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). LPL Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LPL (F-1) antibody targets a protein crucial in lipid metabolism, specifically in hydrolyzing triglycerides found in very low-density lipoproteins and chylomicrons, essential for proper dietary fat utilization. LPL (F-1) monoclonal antibody recognizes a protein primarily synthesized in adipose tissue, heart, and skeletal muscle, where LPL anchors to cell membranes via glycosylphosphatidylinositol (GPI), enabling effective interaction with circulating lipoproteins. Anti-LPL antibody (F-1) serves as an invaluable tool for researchers studying lipid metabolism and associated disorders, as LPL defects can lead to serious conditions like chylomicronemia syndrome, characterized by elevated triglyceride levels.

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LPL Antibody (F-1) References:

1. Sciatic nerve lipoprotein lipase is reduced in streptozotocin-induced diabetes and corrected by insulin.  |  Ferreira, LD., et al. 2002. Endocrinology. 143: 1213-7. PMID: 11897675
2. Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro.  |  McTernan, PG., et al. 2002. Diabetes. 51: 1493-8. PMID: 11978647
3. The lipase gene family.  |  Wong, H. and Schotz, MC. 2002. J Lipid Res. 43: 993-9. PMID: 12091482
4. Lipoprotein lipase and its role in regulation of plasma lipoproteins and cardiac risk.  |  Otarod, JK. and Goldberg, IJ. 2004. Curr Atheroscler Rep. 6: 335-42. PMID: 15296698
5. Lipoprotein lipase and atherosclerosis.  |  Tsutsumi, K. 2003. Curr Vasc Pharmacol. 1: 11-7. PMID: 15320848
6. Calcium triggers folding of lipoprotein lipase into active dimers.  |  Zhang, L., et al. 2005. J Biol Chem. 280: 42580-91. PMID: 16179346
7. Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation.  |  Takahashi, S. 2017. J Atheroscler Thromb. 24: 552-559. PMID: 28428482
8. Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL.  |  Larsson, M., et al. 2017. J Lipid Res. 58: 1893-1902. PMID: 28694296
9. Rare LPL gene missense mutation in an infant with hypertriglyceridemia.  |  Qin, YY., et al. 2018. J Clin Lab Anal. 32: e22414. PMID: 29479812
10. GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity.  |  Kristensen, KK., et al. 2021. Front Cell Dev Biol. 9: 702508. PMID: 34336854
11. Expression and one-step purification of active LPL contemplated by biophysical considerations.  |  Lund Winther, AM., et al. 2021. J Lipid Res. 62: 100149. PMID: 34780727
12. Incidental diagnosis of LPL deficiency in an infant presenting with an acute respiratory infection.  |  Thowfeek Zeenath Thaneefa, M., et al. 2022. Clin Chim Acta. 529: 1-3. PMID: 35085586

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LPL Antibody (F-1) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-LPL Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LPL Antibody (F-1) Specifications

Alternate Product Name: lipoprotein lipase

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 28-80

Epitope Target: LPL

Epitope Species: human

Product Reactivity/Detection: LPL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for LPL Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin