LOXL3 Antibody (H-11): sc-365285
- LOXL3 Antibody (H-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 111-180 mapping near the N-terminus of LOXL3 of human origin
- recommended for detection of LOXL3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for LOXL3 Antibody (H-11) for WB applications. These reagents are now offered in bundles with LOXL3 Antibody (H-11) (see ordering information below).
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LOXL3 Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects lysyl oxidase-like 3 (LOXL3) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LOXL3 is a crucial extracellular protein that plays a significant role in elastogenesis, the process of forming elastic fibers in the extracellular matrix, which is vital for maintaining the structural integrity and elasticity of tissues. LOXL3 is predominantly localized to sites of elastogenesis, highlighting its importance in tissue development and repair. Additionally, LOXL3 interacts with other proteins, such as Snail, to regulate E-cadherin expression, which is essential for maintaining epithelial cell adhesion and preventing epithelial-mesenchymal transition—a key event in tumor progression. LOXL3 expression is widespread, with the highest levels found in the placenta, small intestine, testis, heart, ovary, and spleen, indicating diverse roles in various biological processes. Anti-LOXL3 antibody (H-11) is an invaluable tool for researchers studying the mechanisms of elastogenesis and the implications of LOXL3 in cancer biology and tissue remodeling.
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LOXL3 Antibody (H-11) References:
- Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. | Kraft-Sheleg, O., et al. 2016. Dev Cell. 36: 550-61. PMID: 26954549
- LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer. | Laurentino, TS., et al. 2019. Int J Mol Sci. 20: PMID: 31340433
- Targeted Deletion of Loxl3 by Col2a1-Cre Leads to Progressive Hearing Loss. | Liu, Z., et al. 2021. Front Cell Dev Biol. 9: 683495. PMID: 34150778
- LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells. | Laurentino, TS., et al. 2021. Int J Mol Sci. 22: PMID: 34360836
- Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival. | Vázquez-Naharro, A., et al. 2022. Cancers (Basel). 14: PMID: 35267510
- Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development. | Santamaría, PG., et al. 2022. Int J Mol Sci. 23: PMID: 35628534
- LOXL3-promoted hepatocellular carcinoma progression via promotion of Snail1/USP4-mediated epithelial-mesenchymal transition. | Li, R., et al. 2022. Environ Toxicol. 37: 2540-2551. PMID: 35841383
- N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3. | Shi, HZ., et al. 2022. Clin Transl Med. 12: e1075. PMID: 36324258
- Progressive degeneration of the retina in Loxl3 mutant mouse model of Stickler syndrome. | Liu, Z., et al. 2023. Dev Biol. 495: 54-62. PMID: 36610533
- LOXL3 Inhibits Autophagy of Chondrocytes by Activating Rheb in Osteoarthritis. | Zheng, GP., et al. 2023. Curr Med Sci. 43: 1195-1200. PMID: 38153629
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LOXL3 Antibody (H-11) | sc-365285 | 200 µg/ml | $316.00 | |||
LOXL3 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-540326 | 200 µg Ab; 10 µg BP | $354.00 | |||
LOXL3 Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-542043 | 200 µg Ab; 20 µg BP | $354.00 |