LOXL3 Activators
The chemical class of LOXL3 Activators encompasses a variety of compounds that indirectly influence the activity of LOXL3, an enzyme involved in the crosslinking of collagen and elastin fibers in the extracellular matrix. These activators do not directly interact with LOXL3 but instead modulate various biochemical and cellular processes related to the synthesis, maturation, and maintenance of the extracellular matrix, which in turn can impact LOXL3 activity.
Compounds such as Ascorbic Acid, Copper Sulfate, and Manganese Chloride are crucial for the synthesis and stabilization of collagen, a primary substrate for LOXL3. Their roles range from serving as cofactors for enzymes in the collagen synthesis pathway to enhancing the stability and function of collagen. For instance, Ascorbic Acid is essential for the hydroxylation of proline and lysine residues in collagen, a process necessary for collagen fiber stability, which is a prerequisite for effective crosslinking by LOXL3.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid, or Vitamin C, is crucial for collagen synthesis and maturation. It serves as a cofactor for prolyl and lysyl hydroxylases, enzymes that are necessary for the stability and function of collagen. By supporting collagen synthesis, it may indirectly enhance LOXL3 activity, which is involved in collagen crosslinking. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper is a cofactor for lysyl oxidase, the parent enzyme in the LOX family. Copper sulfate can provide the necessary copper ions to enhance the activity of lysyl oxidase enzymes, including LOXL3. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
BAPN is a lathyrogen that inhibits lysyl oxidase activity. While it is primarily an inhibitor, its presence can modulate collagen and elastin synthesis pathways, potentially impacting LOXL3 activity indirectly through feedback mechanisms. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese is a cofactor for several enzymes involved in the biosynthesis of proteoglycans and glycosaminoglycans in the extracellular matrix. This can indirectly influence LOXL3 activity by affecting the matrix composition. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences gene expression related to extracellular matrix components. Its role in modulating collagen and elastin synthesis could indirectly impact LOXL3 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, can modulate several signaling pathways, including those related to extracellular matrix synthesis. This might indirectly influence LOXL3 activity. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Taurine has been shown to play a role in the modulation of connective tissue growth and function. Its impact on extracellular matrix components could indirectly affect LOXL3 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is essential for numerous enzymes involved in matrix synthesis and remodeling. Zinc sulfate supplementation could influence extracellular matrix dynamics, potentially impacting LOXL3 activity. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium is important for antioxidant defense systems that protect extracellular matrix components. By preserving matrix integrity, selenium may indirectly influence LOXL3 activity. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $95.00 $263.00 $529.00 | ||
Lysine is an amino acid integral to collagen synthesis. Its availability can influence collagen maturation and, subsequently, LOXL3 activity in crosslinking collagen. | ||||||