LMP2 Antibody (B-1): sc-373689
- LMP2 Antibody (B-1) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 193-219 at the C-terminus of LMP2 of human origin
- recommended for detection of LMP2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- m-IgG3 BP-HRP is the preferred secondary detection reagent for LMP2 Antibody (B-1) for WB applications. This reagent is now offered in a bundle with LMP2 Antibody (B-1) (see ordering information below).
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LMP2 Antibody (B-1) is a mouse monoclonal IgG3 antibody that detects LMP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LMP2 is a crucial component of the proteasome, a multicatalytic proteinase complex that plays a vital role in the degradation of ubiquitinated proteins, thereby regulating various cellular processes including the cell cycle, apoptosis, and antigen presentation. The proteasome is located in both the nucleus and cytoplasm, where LMP2 maintains cellular homeostasis by removing damaged or misfolded proteins. LMP2 is expressed in two alternatively spliced forms, LMP2.l and LMP2.s, which can influence proteasome functionality and interaction with the major histocompatibility complex (MHC) class I antigen-processing pathway. Upon stimulation with interferon-gamma, LMP2 can replace housekeeping subunits in the proteasome, enhancing the activation of cytotoxic T cells, which is essential for an effective immune response. LMP2′s ability to form complexes with other proteasome subunits underscores its significance in the immune system and potential as a target for therapeutic interventions in diseases where proteasome function is compromised.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LMP2 Antibody (B-1) | sc-373689 | 200 µg/ml | $322.00 | |||
LMP2 Antibody (B-1): m-IgG3 BP-HRP Bundle | sc-550440 | 200 µg Ab; 40 µg BP | $361.00 | |||
LMP2 (B-1) Neutralizing Peptide | sc-373689 P | 100 µg/0.5 ml | $69.00 |