LMO4 Antibody (4H8): sc-293440

LMO4 Antibody (4H8) is a mouse monoclonal IgG2a antibody that detects LMO4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LMO4 (4H8) antibody is available as the non-conjugated form. LMO4 protein plays a crucial role in the development and differentiation of various cell types, particularly in the central nervous system and immune system. LMO4 is involved in the regulation of gene expression through interaction with other proteins, such as nuclear LIM interactor (NLI), which facilitates the formation of transcriptional regulatory complexes. This interaction is vital for maintaining proper cellular phenotype and function, especially in T cells and neural crest cells, where LMO4 is prominently expressed. LMO4 presence in these cells underscores its importance in processes such as T cell maturation and neural development, making LMO4 a significant target for research in developmental biology and immunology. Using anti-LMO4 antibody (4H8) in your experiments can provide insights into the molecular mechanisms underlying these critical biological processes.

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LMO4 Antibody (4H8) References:

1. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.  |  Boehm, T., et al. 1991. Proc Natl Acad Sci U S A. 88: 4367-71. PMID: 2034676
2. LMO4 mediates trastuzumab resistance in HER2 positive breast cancer cells.  |  Ding, K., et al. 2018. Am J Cancer Res. 8: 594-609. PMID: 29736306
3. Lmo4 Deficiency Enhances Susceptibility to Cisplatin-Induced Cochlear Apoptosis and Hearing Loss.  |  Rosati, R., et al. 2021. Mol Neurobiol. 58: 2019-2029. PMID: 33411315
4. Pro-inflammatory cytokine IL-6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway.  |  Tu, Z., et al. 2023. Immun Inflamm Dis. 11: e1104. PMID: 38156380
5. LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling.  |  Schelker, RC., et al. 2024. Signal Transduct Target Ther. 9: 199. PMID: 39117617
6. Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins.  |  Agulnick, AD., et al. 1996. Nature. 384: 270-2. PMID: 8918878
7. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity.  |  Hinks, GL., et al. 1997. J Neurosci. 17: 5549-59. PMID: 9204936
8. Chromosomal translocations and leukaemia: a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis.  |  Rabbitts, TH., et al. 1997. Leukemia. 11 Suppl 3: 271-2. PMID: 9209362
9. LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1.  |  Osada, H., et al. 1997. Leukemia. 11 Suppl 3: 307-12. PMID: 9209374
10. The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.  |  Jurata, LW., et al. 1998. J Biol Chem. 273: 3152-7. PMID: 9452425
11. Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.  |  Kenny, DA., et al. 1998. Proc Natl Acad Sci U S A. 95: 11257-62. PMID: 9736723
12. Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.  |  Semina, EV., et al. 1998. Mamm Genome. 9: 921-4. PMID: 9799849

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LMO4 Antibody (4H8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LMO4 Antibody (4H8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LMO4 Antibody (4H8) Specifications

Alternate Product Name: LMO4

Product Clone Name: 4H8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a lambda light chain

Amino Acids: 1-165

Epitope Target: LMO4

Epitope Species: human

Product Reactivity/Detection: LMO4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LMO4 Antibody (4H8): N/A