LIS1 Antibody (C-7): sc-393320
- LIS1 Antibody (C-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping near the N-terminus of LIS1 of human origin
- recommended for detection of LIS1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LIS1 Antibody (C-7) for WB applications. These reagents are now offered in bundles with LIS1 Antibody (C-7) (see ordering information below).
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LIS1 Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects LIS1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LIS1 plays a critical role in neuronal migration during brain development, and proper function is essential for the formation of a normal cerebral cortex. Mutations in LIS1 can lead to lissencephaly, a condition characterized by a smooth brain surface and severe cognitive impairments. LIS1 is primarily localized in the cytoplasm and interacts with doublecortin, another protein implicated in neuronal migration. This interaction is vital for the regulation of microtubule dynamics, which are crucial for the movement of neurons to their appropriate locations in the developing brain. Anti-LIS1 antibody (C-7) is an invaluable tool for researchers studying the molecular mechanisms underlying brain development and the pathogenesis of lissencephaly, providing insights into potential therapeutic targets for related neurological disorders.
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LIS1 Antibody (C-7) References:
- The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain development. | Vallee, RB. and Tsai, JW. 2006. Genes Dev. 20: 1384-93. PMID: 16751177
- Overexpression of Lis1 in different stages of spermatogenesis does not result in an aberrant phenotype. | Drusenheimer, N., et al. 2011. Cytogenet Genome Res. 134: 269-82. PMID: 21734362
- LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules. | Reiner, O. 2013. Scientifica (Cairo). 2013: 393975. PMID: 24278775
- Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. | DeSantis, ME., et al. 2017. Cell. 170: 1197-1208.e12. PMID: 28886386
- Lis1 activates dynein motility by modulating its pairing with dynactin. | Elshenawy, MM., et al. 2020. Nat Cell Biol. 22: 570-578. PMID: 32341547
- LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. | Htet, ZM., et al. 2020. Nat Cell Biol. 22: 518-525. PMID: 32341549
- Lis1 co-localizes with actin in the phagocytic cup and regulates phagocytosis. | Chhatre, A., et al. 2020. Cytoskeleton (Hoboken). 77: 249-260. PMID: 32524725
- LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma. | Li, L., et al. 2022. Int J Oncol. 61: PMID: 36102310
- Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. | Reimer, JM., et al. 2023. Elife. 12: PMID: 36692009
- Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography. | Ortug, A., et al. 2023. Brain Sci. 13: PMID: 38137102
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LIS1 Antibody (C-7) | sc-393320 | 200 µg/ml | $322.00 | |||
LIS1 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-538188 | 200 µg Ab; 10 µg BP | $361.00 | |||
LIS1 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-535752 | 200 µg Ab; 40 µg BP | $361.00 | |||
LIS1 Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-545565 | 200 µg Ab; 20 µg BP | $361.00 |