Liprin α1 Antibody (F-1): sc-271373

Liprin α1 Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects Liprin α1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Liprin α1 is a crucial component in cellular signaling, particularly in axon guidance and mammary gland development, as Liprin α1 interacts with members of the leukocyte common antigen-related (LAR) family of transmembrane protein tyrosine phosphatases. This interaction is vital for forming complex structures that serve as scaffolds, facilitating LAR phosphatase recruitment and anchoring. Liprin α1 is ubiquitously expressed and plays a significant role in regulating cell migration, which is essential for processes such as tissue repair and development, and may help prevent metastasis in cancer. The interaction between Liprin α1 and tumor suppressor ING4 highlights Liprin α1′s importance in maintaining cellular integrity and function. Post-translational modifications, such as phosphorylation, can influence Liprin α1′s binding affinity to LAR, with treatments like calf intestinal phosphatase potentially weakening this interaction, thereby affecting downstream signaling pathways. Anti-Liprin α1 antibody (F-1) is an invaluable tool for researchers studying these critical biological processes.

The preferred Liprin α1 antibody is Liprin α1 Antibody (A-6): sc-398030.