LIN-41 Antibody (B-12): sc-393338

LIN-41 Antibody (B-12) is a mouse monoclonal IgG2a antibody that detects LIN-41 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LIN-41, also known as tripartite motif-containing 71 (TRIM71), plays a crucial role in regulating cell fate determination by encoding microRNAs that influence developmental timing. Specifically, LIN-41 is involved in the downregulation of heterochronic genes like let-7 and lin-4, which bind to the 3′ untranslated region of the LIN-41 gene, thereby controlling the expression of LIN-29, a transcription factor essential for adult cell specification. The precise regulation of LIN-41 is vital, as null mutations can lead to the premature development of adult tissues during larval stages, highlighting LIN-41′s importance in developmental biology. LIN-41 is predominantly expressed in various embryonic cell types, with the highest expression levels observed in developing limb buds, tail buds, and brachial arches, underscoring LIN-41′s significance in early developmental processes. Anti-LIN-41 antibody (B-12) is an invaluable tool for researchers studying the intricate mechanisms of gene regulation and developmental timing in various species.

The preferred LIN-41 antibody is LIN-41 Antibody (E-1): sc-393352.