LI-cadherin Antibody (H-1): sc-393533

LI-cadherin Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects LI-cadherin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-LI-cadherin antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LI-cadherin, also known as CDH17, plays a crucial role in cell adhesion, particularly in the liver and intestine, where LI-cadherin is localized to the basolateral domain of hepatocytes and enterocytes. This localization maintains the integrity of epithelial tissues and facilitates intercellular communication, essential for proper tissue function and organization. LI-cadherin′s structure includes a large extracellular domain composed of five homologous repeats, critical for binding specificity, while a short intracellular domain interacts with cytoplasmic proteins like catenin beta to regulate cadherin function. The restricted expression of LI-cadherin to liver and intestinal tissues underscores LI-cadherin′s importance in these organs, making LI-cadherin monoclonal antibody (H-1) an invaluable tool for researchers studying cellular adhesion mechanisms and tissue architecture in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LI-cadherin Antibody (H-1) References:

1. Molecular characteristics of differentiated-type gastric carcinoma with distinct mucin phenotype: LI-cadherin is associated with intestinal phenotype.  |  Motoshita, J., et al. 2006. Pathol Int. 56: 200-5. PMID: 16634965
2. Genomic organization and chromosomal mapping of the mouse P-cadherin gene.  |  Hatta, M., et al. 1991. Nucleic Acids Res. 19: 4437-41. PMID: 1886768
3. Knockdown of LI-cadherin alters expression of matrix metalloproteinase-2 and -9 and galectin-3.  |  Yu, Q., et al. 2016. Mol Med Rep. 13: 4469-74. PMID: 27035870
4. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.  |  Takeichi, M. 1988. Development. 102: 639-55. PMID: 3048970
5. Physiological relevance of epithelial geometry: New insights into the standing gradient model and the role of LI cadherin.  |  Vereshchaga, Y., et al. 2018. PLoS One. 13: e0208791. PMID: 30576326
6. A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis.  |  Lopes, N., et al. 2020. Gastric Cancer. 23: 811-823. PMID: 32215766
7. Desmosomal cadherins: another growing multigene family of adhesion molecules.  |  Koch, PJ. and Franke, WW. 1994. Curr Opin Cell Biol. 6: 682-7. PMID: 7833048
8. Cadherins and catenins: interactions and functions in embryonic development.  |  Ranscht, B. 1994. Curr Opin Cell Biol. 6: 740-6. PMID: 7833053
9. Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.  |  Ayalon, O., et al. 1994. J Cell Biol. 126: 247-58. PMID: 8027182
10. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.  |  Hinck, L., et al. 1994. J Cell Biol. 125: 1327-40. PMID: 8207061
11. Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine.  |  Berndorff, D., et al. 1994. J Cell Biol. 125: 1353-69. PMID: 8207063
12. Morphogenetic roles of classic cadherins.  |  Takeichi, M. 1995. Curr Opin Cell Biol. 7: 619-27. PMID: 8573335

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LI-cadherin Antibody (H-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LI-cadherin Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LI-cadherin Antibody (H-1) Specifications

Alternate Product Name: CDH17

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 666-832

Epitope Target: LI-cadherin

Epitope Species: human

Product Reactivity/Detection: LI-cadherin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LI-cadherin Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin