LI-cadherin Antibody (B-1): sc-393045
- LI-cadherin Antibody (B-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 806-832 at the C-terminus of LI-cadherin of human origin
- recommended for detection of LI-cadherin of human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LI-cadherin Antibody (B-1) for WB and IHC(P) applications. These reagents are now offered in bundles with LI-cadherin Antibody (B-1) (see ordering information below).
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LI-cadherin Antibody (B-1) is a mouse monoclonal IgG2b antibody that detects LI-cadherin (LI-cad) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). LI-cadherin plays a crucial role in maintaining tissue architecture integrity, particularly in the liver and intestine, where LI-cadherin localizes to the basolateral domain of hepatocytes and enterocytes. This localization facilitates tight junction and adherens junction formation, essential for cell adhesion and communication, influencing tissue morphogenesis and function. The extracellular domain of LI-cadherin, characterized by five homologous repeats, enables binding specificity, while the intracellular domain interacts with cytoplasmic proteins such as catenin β, key regulators of cadherin-mediated adhesion. Anti-LI-cadherin antibody (B-1) helps researchers understand cell-cell interaction dynamics and cadherin roles in various physiological and pathological processes, making LI-cadherin (B-1) antibody valuable for developmental biology, cancer research, and tissue engineering studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LI-cadherin Antibody (B-1) References:
- Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. | Ko, S., et al. 2004. Biochem Biophys Res Commun. 319: 562-8. PMID: 15178443
- Altered expression of a Li-cadherin in gastric cancer and intestinal metaplasia. | Dong, W., et al. 2007. Dig Dis Sci. 52: 536-42. PMID: 17226075
- Li-cadherin is inversely correlated with galectin-3 expression in gastric cancer. | Dong, WG., et al. 2008. Dig Dis Sci. 53: 1811-7. PMID: 17999183
- Knockdown of Li-cadherin increases metastatic behaviors of LoVo cells. | Yu, QF., et al. 2010. J Cancer Res Clin Oncol. 136: 1641-9. PMID: 20204409
- LI-cadherin cis-dimerizes in the plasma membrane Ca(2+) independently and forms highly dynamic trans-contacts. | Bartolmäs, T., et al. 2012. Cell Mol Life Sci. 69: 3851-62. PMID: 22842778
- Knockdown of LI-cadherin alters expression of matrix metalloproteinase-2 and -9 and galectin-3. | Yu, Q., et al. 2016. Mol Med Rep. 13: 4469-74. PMID: 27035870
- Water transport through the intestinal epithelial barrier under different osmotic conditions is dependent on LI-cadherin trans-interaction. | Weth, A., et al. 2017. Tissue Barriers. 5: e1285390. PMID: 28452574
- LI-cadherin and CDX2: Useful Markers in Metastatic Gastrointestinal Adenocarcinoma Cells in Serous Cavity Effusion. | Ma, H., et al. 2019. Appl Immunohistochem Mol Morphol. 27: e75-e80. PMID: 30095466
- Mechanism of dimerization and structural features of human LI-cadherin. | Yui, A., et al. 2021. J Biol Chem. 297: 101054. PMID: 34364873
- Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene. | Yui, A., et al. 2023. Sci Rep. 13: 6493. PMID: 37081068
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LI-cadherin Antibody (B-1) | sc-393045 | 200 µg/ml | $322.00 | |||
LI-cadherin Antibody (B-1): m-IgGκ BP-HRP Bundle | sc-535681 | 200 µg Ab; 40 µg BP | $361.00 | |||
LI-cadherin Antibody (B-1): m-IgG2b BP-HRP Bundle | sc-549470 | 200 µg Ab; 10 µg BP | $361.00 | |||
LI-cadherin (B-1) Neutralizing Peptide | sc-393045 P | 100 µg/0.5 ml | $69.00 |