Lex A Antibody (C-11): sc-390386

Lex A Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Lex A in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Lex A antibody (C-11) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for different experimental needs. Lex A, a crucial protein involved in the regulation of gene expression, plays a significant role in bacterial stress response and DNA repair mechanisms. Lex A (C-11) antibody recognizes specific protein interactions, such as with RecA protein, which are vital for maintaining genomic stability and facilitating damaged DNA repair. The interaction between Lex A and RecA helps regulate the SOS response in bacteria, allowing adaptation to environmental stressors. Understanding Lex A function and interactions is essential for elucidating molecular mechanisms underlying bacterial survival and resistance, making Lex A (C-11) monoclonal antibody an invaluable research tool for studying these processes.

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Lex A Antibody (C-11) References:

1. A LexA-related protein regulates redox-sensitive expression of the cyanobacterial RNA helicase, crhR.  |  Patterson-Fortin, LM., et al. 2006. Nucleic Acids Res. 34: 3446-54. PMID: 16840531
2. A Synechocystis LexA-orthologue binds direct repeats in target genes.  |  Patterson-Fortin, LM. and Owttrim, GW. 2008. FEBS Lett. 582: 2424-30. PMID: 18555801
3. Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership.  |  Mo, CY., et al. 2018. ACS Infect Dis. 4: 349-359. PMID: 29275629
4. The Kinetic and Molecular Basis for the Interaction of LexA and Activated RecA Revealed by a Fluorescent Amino Acid Probe.  |  Hostetler, ZM., et al. 2020. ACS Chem Biol. 15: 1127-1133. PMID: 31999086
5. Non-canonical LexA proteins regulate the SOS response in the Bacteroidetes.  |  Sánchez-Osuna, M., et al. 2021. Nucleic Acids Res. 49: 11050-11066. PMID: 34614190
6. Real-time kinetic studies of Mycobacterium tuberculosis LexA-DNA interaction.  |  Chatterjee, C., et al. 2021. Biosci Rep.. PMID: 34750612
7. Real-time kinetic studies of Mycobacterium tuberculosis LexA-DNA interaction.  |  Chatterjee, C., et al. 2021. Biosci Rep. 41: PMID: 34792534
8. Spatial and temporal control of expression with light-gated LOV-LexA.  |  Ribeiro, IMA., et al. 2022. G3 (Bethesda). 12: PMID: 35876796
9. A LexA-based yeast two-hybrid system for studying light-switchable interactions of phytochromes with their interacting partners.  |  Li, H., et al. 2021. aBIOTECH. 2: 105-116. PMID: 36304755
10. Cd-induced cytosolic proteome changes in the cyanobacterium Anabaena sp. PCC7120 are mediated by LexA as one of the regulatory proteins.  |  Srivastava, A., et al. 2023. Biochim Biophys Acta Proteins Proteom. 1871: 140902. PMID: 36716944

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Lex A Antibody (C-11) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Lex A Antibody (C-11) Specifications

Alternate Product Name: Lex A

Product Clone Name: C-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 19-55

Epitope Target: Lex A

Epitope Species: E. coli

Product Reactivity/Detection: Lex A and Lex A fusion proteins

Species Reactivity/Detection: N/A

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Lex A Antibody (C-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Lex A antibody is Lex A Antibody (2-12): sc-7544.