LECT2 Antibody (B-6): sc-398071

LECT2 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects LECT2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LECT2 (B-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The leukocyte cell-derived chemotaxin 2 (LECT2) protein is a secreted molecule known for its role in neutrophil chemotaxis, which is crucial for the immune response and inflammation. LECT2 is predominantly expressed in the liver, where LECT2 exhibits diffuse immunostaining within the cytoplasm of hepatocytes, highlighting LECT2′s importance in liver function and pathology. Structurally, LECT2 consists of 133 amino acids and features three intramolecular disulfide bonds that contribute to LECT2′s stability and functional versatility. Notably, homologues of LECT2 have been identified across various vertebrate species, indicating LECT2′s evolutionary significance. The multifunctional role of LECT2 encompasses processes such as cell growth, differentiation, tissue damage repair, carcinogenesis, and the modulation of autoimmune diseases. Furthermore, LECT2 expression is specifically induced in the liver through β-catenin signaling pathways, and elevated serum levels of LECT2 have been associated with liver recovery, suggesting LECT2′s potential utility as a prognostic biomarker in liver-related conditions.

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LECT2 Antibody (B-6) References:

1. [Anomalous origin of the right pulmonary artery from the ascending aorta; report of a successful corrective surgery].  |  Kishimoto, H., et al. 1976. Nihon Kyobu Geka Gakkai Zasshi. 24: 1519-27. PMID: 1035596
2. Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis.  |  Saito, T., et al. 2004. J Immunol. 173: 579-85. PMID: 15210819
3. Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver.  |  Ovejero, C., et al. 2004. Hepatology. 40: 167-76. PMID: 15239100
4. Changes in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation.  |  Sato, Y., et al. 2004. Transplant Proc. 36: 2357-8. PMID: 15561248
5. Serum LECT2 level as a prognostic indicator in acute liver failure.  |  Sato, Y., et al. 2004. Transplant Proc. 36: 2359-61. PMID: 15561249
6. Molecular cloning of leukocyte cell-derived chemotaxin 2 in rainbow trout.  |  Kokkinos, PA., et al. 2005. Fish Shellfish Immunol. 18: 371-80. PMID: 15683915
7. Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene.  |  Yamagoe, S., et al. 1998. Genomics. 48: 324-9. PMID: 9545637
8. The mouse Lect2 gene: cloning of cDNA and genomic DNA, structural characterization and chromosomal localization.  |  Yamagoe, S., et al. 1998. Gene. 216: 171-8. PMID: 9714793
9. Expression, oxidative refolding, and characterization of six-histidine-tagged recombinant human LECT2, a 16-kDa chemotactic protein with three disulfide bonds.  |  Ito, M., et al. 2003. Protein Expr Purif. 27: 272-8. PMID: 12597887

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LECT2 Antibody (B-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-LECT2 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LECT2 Antibody (B-6) Specifications

Alternate Product Name: LECT2

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 48-75

Epitope Target: LECT2

Epitope Species: human

Product Reactivity/Detection: mature LECT2 and LECT2 precursor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for LECT2 Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin