LDOC1 Antibody (2507C1a): sc-81103

LDOC1 Antibody (2507C1a) is a mouse monoclonal IgG2a antibody that detects LDOC1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-LDOC1 antibody (2507C1a) is available as a non-conjugated format. LDOC1, known as leucine zipper protein down-regulated in cancer cells, consists of 146 amino acids and is encoded by the human gene LDOC1. LDOC1 features a leucine zipper-like motif and a proline-rich region that exhibits significant similarity to an SH3-binding domain, which is crucial for protein-protein interactions. Localized primarily in the nucleus, LDOC1 plays a vital role in regulating the transcriptional response mediated by nuclear factor kB (NF-kB), a key player in inflammatory and immune responses. Down-regulation of LDOC1 in certain cancer cell lines suggests a potential function as a tumor suppressor gene, indicating LDOC1 may be integral to the development and progression of various cancers. Understanding LDOC1 function and interactions within the cellular environment is essential for elucidating LDOC1′s role in cancer biology and may provide insights into novel therapeutic strategies.

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LDOC1 Antibody (2507C1a) References:

1. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines.  |  Nagasaki, K., et al. 1999. Cancer Lett. 140: 227-34. PMID: 10403563
2. Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis.  |  Nagasaki, K., et al. 2003. Int J Cancer. 105: 454-8. PMID: 12712434
3. Protein partners of C/EBPepsilon.  |  Chih, DY., et al. 2004. Exp Hematol. 32: 1173-81. PMID: 15588942
4. LDOC1, a novel MZF-1-interacting protein, induces apoptosis.  |  Inoue, M., et al. 2005. FEBS Lett. 579: 604-8. PMID: 15670815
5. A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region.  |  Baffoe-Bonnie, AB., et al. 2005. Hum Genet. 117: 307-16. PMID: 15906096
6. WAVE3 functions as a negative regulator of LDOC1.  |  Mizutani, K., et al. 2005. J Biochem. 138: 639-46. PMID: 16272576

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LDOC1 Antibody (2507C1a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LDOC1 Antibody (2507C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LDOC1 Antibody (2507C1a) Specifications

Alternate Product Name: LDOC1

Product Clone Name: 2507C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: LDOC1

Epitope Species: human

Product Reactivity/Detection: LDOC1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LDOC1 Antibody (2507C1a): N/A