LCOR Antibody (G-4): sc-515594

LCOR Antibody (G-4) is a mouse monoclonal IgA antibody that detects LCOR (Ligand-dependent corepressor) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LCOR is a 433 amino acid transcriptional corepressor characterized by its LXXLL motif, nuclear localization signal, and helix-loop-helix domain, which are crucial for regulating gene expression. LCOR (G-4) antibody targets a protein predominantly expressed in both fetal and adult tissues, where LCOR plays a vital role in modulating nuclear receptor activity, particularly estrogen receptors ERα and ERβ, in the presence of estradiol. By acting as a molecular scaffold, LCOR facilitates the recruitment of various proteins essential for transcriptional repression, thereby influencing cellular responses to hormonal signals. Notably, LCOR′s activity is subject to inhibition by the histone deacetylase inhibitor trichostatin A, indicating a receptor-dependent mechanism of action that underscores LCOR′s importance in maintaining a negative feedback loop to mitigate hormone-induced transactivation. Anti-LCOR antibody (G-4) serves as an invaluable tool for researchers exploring the intricate regulatory networks involving this corepressor and its implications in various biological processes.

The preferred LCOR antibody is LCOR Antibody (C-6): sc-377019.