LATS1 Antibody (G-12): sc-398560

LATS1 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects LATS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-LATS1 antibody (G-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LATS1, a homolog of the Drosophila tumor suppressor protein lats, functions as a serine/threonine kinase that plays a crucial role in regulating cell growth and cell cycle. LATS1′s ability to inhibit Cdc2 activity during early mitosis is vital for maintaining proper cell division and preventing uncontrolled proliferation, which is a hallmark of cancer. Studies show that LATS1-deficient mice exhibit heightened sensitivity to carcinogenic treatments and develop various tumors, including soft-tissue sarcomas and ovarian stromal cell tumors, highlighting LATS1′s essential role in tumor suppression and consequences of dysregulation in mammalian systems.

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LATS1 Antibody (G-12) References:

1. cot-1, a gene required for hyphal elongation in Neurospora crassa, encodes a protein kinase.  |  Yarden, O., et al. 1992. EMBO J. 11: 2159-66. PMID: 1534751
2. The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle.  |  Johnston, LH., et al. 1990. Mol Cell Biol. 10: 1358-66. PMID: 2181271
3. A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.  |  Li, RH., et al. 2021. Cell Res. 31: 1088-1105. PMID: 34267352
4. The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.  |  Han, H., et al. 2022. Nat Cell Biol. 24: 74-87. PMID: 35027733
5. Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway.  |  Tong, G., et al. 2022. Pharmacol Res. 178: 106139. PMID: 35202822
6. LATS1 is a central signal transmitter for achieving full type-I interferon activity.  |  Zuo, Y., et al. 2022. Sci Adv. 8: eabj3887. PMID: 35394840
7. The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer.  |  Xu, Y., et al. 2023. J Exp Clin Cancer Res. 42: 10. PMID: 36609396
8. S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway.  |  Tao, YP., et al. 2023. Oncogene. 42: 3491-3502. PMID: 37828220
9. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.  |  Xu, T., et al. 1995. Development. 121: 1053-63. PMID: 7743921
10. The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition.  |  Toyn, JH. and Johnston, LH. 1994. EMBO J. 13: 1103-13. PMID: 8131744
11. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.  |  Tao, W., et al. 1999. Nat Genet. 21: 177-81. PMID: 9988268
12. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.  |  St John, MA., et al. 1999. Nat Genet. 21: 182-6. PMID: 9988269

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LATS1 Antibody (G-12) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-LATS1 Antibody (G-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LATS1 Antibody (G-12) Specifications

Alternate Product Name: Large Tumor Suppressor Kinase 1

Product Clone Name: G-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 3-28

Epitope Target: LATS1

Epitope Species: human

Product Reactivity/Detection: LATS1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for LATS1 Antibody (G-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin