Latrophilin-3 Antibody (B-6): sc-393576
- Latrophilin-3 Antibody (B-6) is a mouse monoclonal IgG2a κ Latrophilin-3 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 547-623 mapping within an internal region of Latrophilin-3 of human origin
- Latrophilin-3 Antibody (B-6) is recommended for detection of all Latrophilin-3 isoforms of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-Latrophilin-3 Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Latrophilin-3 Antibody (B-6) for WB applications. These reagents are now offered in bundles with Latrophilin-3 Antibody (B-6) (see ordering information below).
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Latrophilin-3 Antibody (B-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects Latrophilin-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Latrophilin-3 antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Latrophilin-3 is a member of the latrophilin family of G protein-coupled receptors, which play crucial roles in cell signaling and communication. Latrophilin-3 protein is primarily located in the brain, where Latrophilin-3 is involved in synaptic transmission and neuronal development. Brain-specific expression of Latrophilin-3 suggests a specialized role in the central nervous system, potentially influencing processes such as synaptic plasticity and neurodevelopmental disorders. Research on Latrophilin-3 function and localization can provide insights into neurological diseases and may offer therapeutic targets for intervention.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Latrophilin-3 Antibody (B-6) References:
- The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. | Matsushita, H., et al. 1999. FEBS Lett. 443: 348-52. PMID: 10025961
- Alpha-latrotoxin and its receptors CIRL (latrophilin) and neurexin 1 alpha mediate effects on secretion through multiple mechanisms. | Bittner, MA. 2000. Biochimie. 82: 447-52. PMID: 10865131
- alpha-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin. | Van Renterghem, C., et al. 2000. Eur J Neurosci. 12: 3953-62. PMID: 11069591
- alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. | Südhof, TC. 2001. Annu Rev Neurosci. 24: 933-62. PMID: 11520923
- Spiders of medical importance in the Asia-Pacific: atracotoxin, latrotoxin and related spider neurotoxins. | Nicholson, GM. and Graudins, A. 2002. Clin Exp Pharmacol Physiol. 29: 785-94. PMID: 12165044
- The multiple actions of black widow spider toxins and their selective use in neurosecretion studies. | Ushkaryov, YA., et al. 2004. Toxicon. 43: 527-42. PMID: 15066411
- Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins. | Sando, R., et al. 2019. Science. 363: PMID: 30792275
- Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum. | Zhang, RS., et al. 2020. Elife. 9: PMID: 32202499
- Latrophilin-3 disruption: Effects on brain and behavior. | Regan, SL., et al. 2021. Neurosci Biobehav Rev. 127: 619-629. PMID: 34022279
- Alternative splicing of latrophilin-3 controls synapse formation. | Wang, S., et al. 2024. Nature. 626: 128-135. PMID: 38233523
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Latrophilin-3 Antibody (B-6) | sc-393576 | 200 µg/ml | $322.00 | |||
Latrophilin-3 Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-530505 | 200 µg Ab; 10 µg BP | $361.00 | |||
Latrophilin-3 Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-524007 | 200 µg Ab, 40 µg BP | $361.00 | |||
Latrophilin-3 Antibody (B-6): m-IgG2a BP-HRP Bundle | sc-547513 | 200 µg Ab; 10 µg BP | $361.00 | |||
Latrophilin-3 Antibody (B-6) AC | sc-393576 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Latrophilin-3 Antibody (B-6) HRP | sc-393576 HRP | 200 µg/ml | $322.00 | |||
Latrophilin-3 Antibody (B-6) FITC | sc-393576 FITC | 200 µg/ml | $336.00 | |||
Latrophilin-3 Antibody (B-6) PE | sc-393576 PE | 200 µg/ml | $349.00 | |||
Latrophilin-3 Antibody (B-6) Alexa Fluor® 488 | sc-393576 AF488 | 200 µg/ml | $364.00 | |||
Latrophilin-3 Antibody (B-6) Alexa Fluor® 546 | sc-393576 AF546 | 200 µg/ml | $364.00 | |||
Latrophilin-3 Antibody (B-6) Alexa Fluor® 594 | sc-393576 AF594 | 200 µg/ml | $364.00 | |||
Latrophilin-3 Antibody (B-6) Alexa Fluor® 647 | sc-393576 AF647 | 200 µg/ml | $364.00 | |||
Latrophilin-3 Antibody (B-6) Alexa Fluor® 680 | sc-393576 AF680 | 200 µg/ml | $364.00 | |||
Latrophilin-3 Antibody (B-6) Alexa Fluor® 790 | sc-393576 AF790 | 200 µg/ml | $364.00 |