LARP7 Antibody (G-3): sc-514760

LARP7 Antibody (G-3) is a mouse monoclonal IgG1 antibody that detects LARP7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LARP7, also known as PIP7S or HDCMA18P, is a 582 amino acid protein that plays a crucial role in gene expression regulation by localizing to the nucleoplasm and forming part of the 7SK ribonucleoprotein complex. This complex is essential for RNA polymerase II function, as LARP7 binds to the highly conserved 3′-terminal U-rich stretch of 7SK RNA, effectively sequestering positive elongation factors and thereby repressing transcription of Pol II genes. LARP7′s ability to modulate transcription and elongation is vital for cell growth and has implications in tumorigenesis, making LARP7 significant in cancer research. Additionally, LARP7 undergoes DNA damage-dependent phosphorylation, likely mediated by ATM or ATR, which further highlights LARP7′s importance in cellular responses to stress and potential therapeutic targets. With versatile applications and a critical role in transcriptional regulation, anti-LARP7 antibody (G-3) serves as an invaluable tool for researchers studying gene expression and its implications in various biological processes.

The preferred LARP7 antibody is LARP7 Antibody (E-5): sc-515209.