LARP1 Antibody (A-8): sc-515873
- LARP1 Antibody (A-8) is a mouse monoclonal IgG1 κ LARP1 antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 179-250 mapping near the N-terminus of LARP1 of human origin
- LARP1 Antibody (A-8) is recommended for detection of LARP1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-LARP1 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LARP1 Antibody (A-8) for WB and IHC(P) applications. These reagents are now offered in bundles with LARP1 Antibody (A-8) (see ordering information below).
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LARP1 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects LARP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-LARP1 antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. La-related protein 1 (LARP1), also known as KIAA0731, is a 1,096 amino acid protein that plays a crucial role in RNA metabolism, particularly in stabilizing and folding RNA molecules, which is vital for proper gene expression and cellular function. LARP1 contains two conserved regions, one sharing homology with La/SSB proteins, and features a helix-turn-helix (HTH) La-type RNA-binding domain that suggests involvement in RNA interactions. LARP1 undergoes phosphorylation by ATR or ATM in response to DNA damage, highlighting a role in cellular stress responses. LARP1 interacts with several signaling intermediates, including 14-3-3 β, 14-3-3 γ, and 14-3-3 θ, which are essential for various cellular processes. LARP1 shows widespread expression, with highest levels in heart tissue, and exists as three isoforms produced by alternative splicing, further underscoring functional diversity in different tissues.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LARP1 Antibody (A-8) References:
- dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions. | Chauvet, S., et al. 2000. Dev Dyn. 218: 401-13. PMID: 10878606
- Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA. | Horke, S., et al. 2004. J Biol Chem. 279: 26563-70. PMID: 15060081
- Large-scale characterization of HeLa cell nuclear phosphoproteins. | Beausoleil, SA., et al. 2004. Proc Natl Acad Sci U S A. 101: 12130-5. PMID: 15302935
- Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. | Jin, J., et al. 2004. Curr Biol. 14: 1436-50. PMID: 15324660
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. | Matsuoka, S., et al. 2007. Science. 316: 1160-6. PMID: 17525332
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | Nagase, T., et al. 1998. DNA Res. 5: 277-86. PMID: 9872452
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LARP1 Antibody (A-8) | sc-515873 | 200 µg/ml | $322.00 | |||
LARP1 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-531542 | 200 µg Ab; 10 µg BP | $361.00 | |||
LARP1 Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-525257 | 200 µg Ab, 40 µg BP | $361.00 | |||
LARP1 Antibody (A-8): m-IgG1 BP-HRP Bundle | sc-544613 | 200 µg Ab; 20 µg BP | $361.00 | |||
LARP1 Antibody (A-8) AC | sc-515873 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LARP1 Antibody (A-8) HRP | sc-515873 HRP | 200 µg/ml | $322.00 | |||
LARP1 Antibody (A-8) FITC | sc-515873 FITC | 200 µg/ml | $336.00 | |||
LARP1 Antibody (A-8) PE | sc-515873 PE | 200 µg/ml | $349.00 | |||
LARP1 Antibody (A-8) Alexa Fluor® 488 | sc-515873 AF488 | 200 µg/ml | $364.00 | |||
LARP1 Antibody (A-8) Alexa Fluor® 546 | sc-515873 AF546 | 200 µg/ml | $364.00 | |||
LARP1 Antibody (A-8) Alexa Fluor® 594 | sc-515873 AF594 | 200 µg/ml | $364.00 | |||
LARP1 Antibody (A-8) Alexa Fluor® 647 | sc-515873 AF647 | 200 µg/ml | $364.00 | |||
LARP1 Antibody (A-8) Alexa Fluor® 680 | sc-515873 AF680 | 200 µg/ml | $364.00 | |||
LARP1 Antibody (A-8) Alexa Fluor® 790 | sc-515873 AF790 | 200 µg/ml | $364.00 |