LAR Antibody (7): sc-135969

LAR Antibody (7) is a mouse monoclonal IgG2a kappa light chain antibody that detects LAR protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-LAR antibody (7) is available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP) conjugates, to suit a range of experimental needs. LAR protein, a member of the protein tyrosine phosphatase (PTP) family, plays a crucial role in cellular signaling pathways, particularly in the regulation of insulin receptor phosphorylation, which is vital for glucose homeostasis and metabolic regulation. Located primarily in the cell membrane, LAR functions as a transmembrane protein to interact with various signaling molecules, thereby influencing processes such as cell growth, differentiation, and migration. LAR′s importance in these pathways underscores its potential as a therapeutic target in conditions like diabetes and cancer, where insulin signaling and cell proliferation are disrupted. LAR interacts with other PTPs, such as PTPα and PTPµ, which may further modulate activity and impact on cellular functions. LAR (7) monoclonal antibody enables valuable insights into the complex regulatory mechanisms of PTPs and their implications in health and disease.

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LAR Antibody (7) References:

1. The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting.  |  Mooney, RA. and LeVea, CM. 2003. Curr Top Med Chem. 3: 809-19. PMID: 12678846
2. Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests.  |  Kolkman, MJ., et al. 2004. Behav Brain Res. 154: 171-82. PMID: 15302123
3. Emergent Synapse Organizers: LAR-RPTPs and Their Companions.  |  Han, KA., et al. 2016. Int Rev Cell Mol Biol. 324: 39-65. PMID: 27017006
4. LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.  |  Sclip, A. and Südhof, TC. 2020. Elife. 9: PMID: 31985401
5. Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features.  |  Vtorushin, S., et al. 2022. J Zhejiang Univ Sci B. 23: 617-624. PMID: 35953756
6. Inhibition of LAR attenuates neuroinflammation through RhoA/IRS-1/Akt signaling pathway after intracerebral hemorrhage in mice.  |  Le, C., et al. 2023. J Cereb Blood Flow Metab. 43: 869-881. PMID: 36802818
7. Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin.  |  Milev, P., et al. 1995. J Biol Chem. 270: 24650-3. PMID: 7559574
8. Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu.  |  Elson, A. and Leder, P. 1995. J Biol Chem. 270: 26116-22. PMID: 7592814
9. Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.  |  Brady-Kalnay, SM., et al. 1995. J Cell Biol. 130: 977-86. PMID: 7642713
10. Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects.  |  Ahmad, F., et al. 1995. J Clin Invest. 95: 2806-12. PMID: 7769120
11. Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.  |  Zondag, GC., et al. 1995. J Biol Chem. 270: 14247-50. PMID: 7782276
12. Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester.  |  den Hertog, J., et al. 1995. Cell Growth Differ. 6: 303-7. PMID: 7794797

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LAR Antibody (7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-LAR Antibody (7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LAR Antibody (7) Specifications

Alternate Product Name: LAR

Product Clone Name: 7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 24-196

Epitope Target: LAR

Epitope Species: human

Product Reactivity/Detection: LAR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for LAR Antibody (7): AC: Agarose, HRP: Horseradish Peroxidase