LAPSER1 Antibody (D-7): sc-514618
- LAPSER1 Antibody (D-7) is a mouse monoclonal IgG1 κ LAPSER1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 166-185 within an internal region of LAPSER1 of human origin
- LAPSER1 Antibody (D-7) is recommended for detection of LAPSER1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LAPSER1 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LAPSER1 Antibody (D-7) for WB applications. These reagents are now offered in bundles with LAPSER1 Antibody (D-7) (see ordering information below).
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LAPSER1 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects LAPSER1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LAPSER1 Antibody (D-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LAPSER1, also known as Leucine zipper putative tumor suppressor 2, is a member of the LZTS family and plays a crucial role in cytokinesis, which is the process of cell division. Disruption of LAPSER1 can lead to mislocalization of essential proteins like p80 katanin, resulting in malformation of the central spindle and potentially contributing to carcinogenesis. LAPSER1 is highly expressed in testis and prostate, with lower levels found in spleen, thymus, uterus, small intestine, and colon. LAPSER1 has been implicated as a tumor suppressor due to deletion in various cancers, including prostate tumors, and overexpression in cancer cell lines has been shown to inhibit growth and reduce colony-forming efficiency. LAPSER1′s interaction with proteins such as γ-tubulin and MKLP-1 further underscores LAPSER1′s importance in maintaining cellular integrity during division.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LAPSER1 Antibody (D-7) References:
- LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. | Cabeza-Arvelaiz, Y., et al. 2001. Oncogene. 20: 6707-17. PMID: 11709705
- In silico characterization of LZTS3, a potential tumor suppressor. | Teufel, A., et al. 2005. Oncol Rep. 14: 547-51. PMID: 16012743
- LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin. | Thyssen, G., et al. 2006. Mol Cell Biol. 26: 8857-67. PMID: 17000760
- LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. | Sudo, H. and Maru, Y. 2007. FASEB J. 21: 2086-100. PMID: 17351128
- The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b. | Iida, M., et al. 2007. Toxicol Sci. 99: 43-50. PMID: 17533171
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAPSER1 Antibody (D-7) | sc-514618 | 200 µg/ml | $322.00 | |||
LAPSER1 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-531177 | 200 µg Ab; 10 µg BP | $361.00 | |||
LAPSER1 Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-524791 | 200 µg Ab, 40 µg BP | $361.00 | |||
LAPSER1 Antibody (D-7) AC | sc-514618 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LAPSER1 Antibody (D-7) HRP | sc-514618 HRP | 200 µg/ml | $322.00 | |||
LAPSER1 Antibody (D-7) FITC | sc-514618 FITC | 200 µg/ml | $336.00 | |||
LAPSER1 Antibody (D-7) PE | sc-514618 PE | 200 µg/ml | $349.00 | |||
LAPSER1 Antibody (D-7) Alexa Fluor® 488 | sc-514618 AF488 | 200 µg/ml | $364.00 | |||
LAPSER1 Antibody (D-7) Alexa Fluor® 546 | sc-514618 AF546 | 200 µg/ml | $364.00 | |||
LAPSER1 Antibody (D-7) Alexa Fluor® 594 | sc-514618 AF594 | 200 µg/ml | $364.00 | |||
LAPSER1 Antibody (D-7) Alexa Fluor® 647 | sc-514618 AF647 | 200 µg/ml | $364.00 | |||
LAPSER1 Antibody (D-7) Alexa Fluor® 680 | sc-514618 AF680 | 200 µg/ml | $364.00 | |||
LAPSER1 Antibody (D-7) Alexa Fluor® 790 | sc-514618 AF790 | 200 µg/ml | $364.00 | |||
LAPSER1 (D-7) Neutralizing Peptide | sc-514618 P | 100 µg/0.5 ml | $69.00 |