LAP3 Antibody (E-9): sc-398601

LAP3 Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects LAP3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LAP3, also known as leucine aminopeptidase 3 or PEPS, is a 519 amino acid protein that plays a crucial role in the cytoplasm as a member of the peptidase M17 family. LAP3 exists as a homohexamer and utilizes zinc as a cofactor to catalyze the removal of an N-terminal proline from target peptides, thereby participating in the processing and turnover of intracellular proteins, which is vital for maintaining cellular homeostasis and regulating protein function. The gene encoding LAP3 is located on human chromosome 4, a region that is significant not only for its size, encompassing nearly 6% of the human genome, but also for its association with various genetic disorders, including Huntington′s disease and polycystic kidney disease. Multiple isoforms of LAP3 arise from alternative splicing, highlighting the complexity and regulatory potential of LAP3 in various biological contexts. Anti-LAP3 antibody (E-9) is an essential tool for researchers investigating the functional dynamics of LAP3 in health and disease.

The preferred LAP3 antibody is LAP3 Antibody (D-3): sc-376270.