LAP3 Antibody (D-3): sc-376270
- LAP3 Antibody (D-3) is a mouse monoclonal IgG1 κ LAP3 antibody, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 67-105 within an internal region of LAP3 of human origin
- LAP3 Antibody (D-3) is recommended for detection of LAP3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-LAP3 Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LAP3 Antibody (D-3) for WB and IHC(P) applications. These reagents are now offered in bundles with LAP3 Antibody (D-3) (see ordering information below).
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SEE ALSO...
LAP3 Antibody (D-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects LAP3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). LAP3 (D-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LAP3, also known as leucine aminopeptidase 3, is a 519 amino acid enzyme that plays a crucial role in protein metabolism by catalyzing the removal of N-terminal proline residues from peptides, which is essential for proper turnover and processing of intracellular proteins. This enzymatic activity is vital for maintaining cellular homeostasis and regulating various biological processes, including protein degradation and signaling pathways. LAP3 is located in the cytoplasm and exists as a homohexamer, utilizing zinc as a cofactor for catalytic function. The gene encoding LAP3 is situated on human chromosome 4, a region known for significant gene deserts and associations with various genetic disorders, including Huntington′s disease and polycystic kidney disease. Multiple isoforms of LAP3 arise from alternative splicing, further underscoring the complexity and regulatory potential of this important protein.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LAP3 Antibody (D-3) References:
- Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase. | Matsushima, M., et al. 1991. Biochem Biophys Res Commun. 178: 1459-64. PMID: 1908238
- Immunoaffinity purification and characterization of leucine aminopeptidase from human liver. | Kohno, H., et al. 1986. J Biol Chem. 261: 10744-8. PMID: 3733731
- Human red cell peptidases. | Lewis, WH. and Harris, H. 1967. Nature. 215: 351-5. PMID: 6058286
- Suggested assignment of peptidase S (PEPS) to 4p11-4q12 by exclusion using gene dosage, accounting for variability in fibroblasts. | Schmutz, SM. and Simpson, NE. 1983. Hum Genet. 64: 134-8. PMID: 6350155
- Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids. | Shows, TB., et al. 1978. Hum Genet. 43: 119-25. PMID: 689684
- Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine aminopeptidase by x-ray crystallography. | Kim, H. and Lipscomb, WN. 1993. Proc Natl Acad Sci U S A. 90: 5006-10. PMID: 8506345
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAP3 Antibody (D-3) | sc-376270 | 200 µg/ml | $316.00 | |||
LAP3 Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-529846 | 200 µg Ab; 10 µg BP | $354.00 | |||
LAP3 Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-522903 | 200 µg Ab, 40 µg BP | $354.00 | |||
LAP3 Antibody (D-3) AC | sc-376270 AC | 500 µg/ml, 25% agarose | $416.00 | |||
LAP3 Antibody (D-3) HRP | sc-376270 HRP | 200 µg/ml | $316.00 | |||
LAP3 Antibody (D-3) FITC | sc-376270 FITC | 200 µg/ml | $330.00 | |||
LAP3 Antibody (D-3) PE | sc-376270 PE | 200 µg/ml | $343.00 | |||
LAP3 Antibody (D-3) Alexa Fluor® 488 | sc-376270 AF488 | 200 µg/ml | $357.00 | |||
LAP3 Antibody (D-3) Alexa Fluor® 546 | sc-376270 AF546 | 200 µg/ml | $357.00 | |||
LAP3 Antibody (D-3) Alexa Fluor® 594 | sc-376270 AF594 | 200 µg/ml | $357.00 | |||
LAP3 Antibody (D-3) Alexa Fluor® 647 | sc-376270 AF647 | 200 µg/ml | $357.00 | |||
LAP3 Antibody (D-3) Alexa Fluor® 680 | sc-376270 AF680 | 200 µg/ml | $357.00 | |||
LAP3 Antibody (D-3) Alexa Fluor® 790 | sc-376270 AF790 | 200 µg/ml | $357.00 | |||
LAP3 (D-3) Neutralizing Peptide | sc-376270 P | 100 µg/0.5 ml | $68.00 |