Laminin γ-1 Antibody (B-4): sc-13144
- Laminin γ-1 Antibody (B-4) is a mouse monoclonal IgG2a κ, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 1420-1609 of Laminin γ-1 of human origin
- Anti-Laminin gamma-1 Antibody (B-4) is recommended for detection of Laminin γ-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Laminin gamma-1 Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Laminin γ-1 Antibody (B-4) for WB and IHC(P) applications. These reagents are now offered in bundles with Laminin γ-1 Antibody (B-4) (see ordering information below).
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Laminin γ-1 Antibody (B-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Laminin γ-1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Laminin γ-1 (B-4) antibody is available in non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Laminin γ-1 plays a crucial role in forming and maintaining basement membranes, which are specialized extracellular matrices providing structural support to tissues and influencing cellular behaviors like proliferation, migration, and differentiation. These basement membranes contain laminins, heterotrimeric proteins made up of alpha, beta, and gamma chains that interact with cell surface receptors, including integrins and dystroglycan, to mediate essential cellular functions. Proper assembly and function of laminins are vital for tissue integrity and repair, helping establish tissue architecture and facilitate communication between cells and their extracellular environment. The human laminin gamma-1 gene is located on chromosome 1q31 and is expressed in various tissues, highlighting its importance in normal physiology and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Laminin γ-1 Antibody (B-4) References:
- Role of laminin isoforms in glomerular structure. | Hansen, K. and Abrass, CK. 1999. Pathobiology. 67: 84-91. PMID: 10023136
- Form and function: the laminin family of heterotrimers. | Colognato, H. and Yurchenco, PD. 2000. Dev Dyn. 218: 213-34. PMID: 10842354
- Transcriptional regulation of laminin gene expression. | Aberdam, D., et al. 2000. Microsc Res Tech. 51: 228-37. PMID: 11054873
- Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes. | Lössl, P., et al. 2014. PLoS One. 9: e112886. PMID: 25387007
- The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis. | Fields, B., et al. 2019. Sci Rep. 9: 19303. PMID: 31848396
- A Serological Biomarker of Laminin Gamma 1 Chain Degradation Reflects Altered Basement Membrane Remodeling in Crohn's Disease and DSS Colitis. | Lindholm, M., et al. 2022. Dig Dis Sci. 67: 3662-3671. PMID: 34561759
- Oligodendrocyte-derived laminin-γ1 regulates the blood-brain barrier and CNS myelination in mice. | Kang, M. and Yao, Y. 2024. Cell Rep. 43: 114123. PMID: 38635399
- The laminin family. | Tryggvason, K. 1993. Curr Opin Cell Biol. 5: 877-82. PMID: 8240830
- Role of laminin in endothelial cell recognition and differentiation. | Schnaper, HW., et al. 1993. Kidney Int. 43: 20-5. PMID: 8433560
- Domains of laminin. | Engvall, E. and Wewer, UM. 1996. J Cell Biochem. 61: 493-501. PMID: 8806072
- Laminin and the mechanism of neuronal outgrowth. | Luckenbill-Edds, L. 1997. Brain Res Brain Res Rev. 23: 1-27. PMID: 9063584
- Laminin isoforms and epithelial development. | Ekblom, M., et al. 1998. Ann N Y Acad Sci. 857: 194-211. PMID: 9917842
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin γ-1 Antibody (B-4) | sc-13144 | 200 µg/ml | $316.00 | |||
Laminin γ-1 Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-520607 | 200 µg Ab, 40 µg BP | $354.00 | |||
Laminin γ-1 Antibody (B-4): m-IgG2a BP-HRP Bundle | sc-546083 | 200 µg Ab; 10 µg BP | $354.00 | |||
Laminin γ-1 Antibody (B-4) AC | sc-13144 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Laminin γ-1 Antibody (B-4) HRP | sc-13144 HRP | 200 µg/ml | $316.00 | |||
Laminin γ-1 Antibody (B-4) FITC | sc-13144 FITC | 200 µg/ml | $330.00 | |||
Laminin γ-1 Antibody (B-4) PE | sc-13144 PE | 200 µg/ml | $343.00 | |||
Laminin γ-1 Antibody (B-4) Alexa Fluor® 488 | sc-13144 AF488 | 200 µg/ml | $357.00 | |||
Laminin γ-1 Antibody (B-4) Alexa Fluor® 546 | sc-13144 AF546 | 200 µg/ml | $357.00 | |||
Laminin γ-1 Antibody (B-4) Alexa Fluor® 594 | sc-13144 AF594 | 200 µg/ml | $357.00 | |||
Laminin γ-1 Antibody (B-4) Alexa Fluor® 647 | sc-13144 AF647 | 200 µg/ml | $357.00 | |||
Laminin γ-1 Antibody (B-4) Alexa Fluor® 680 | sc-13144 AF680 | 200 µg/ml | $357.00 | |||
Laminin γ-1 Antibody (B-4) Alexa Fluor® 790 | sc-13144 AF790 | 200 µg/ml | $357.00 |