Laminin γ-1 Antibody (3E10): sc-65643

Laminin γ-1 Antibody (3E10) is a rat monoclonal IgG1 antibody that detects Laminin γ-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Laminin γ-1 plays a crucial role in the formation and maintenance of basement membranes, which are specialized extracellular matrices that provide structural support to tissues and influence various cellular processes. These membranes are essential for tissue integrity and function, as they regulate cell adhesion, migration, and differentiation. The unique structure of Laminin γ-1, which consists of a heterotrimeric assembly of alpha, beta, and gamma chains, allows for interaction with other matrix components and cell surface receptors, facilitating the self-assembly of basement membranes. This interaction is vital for the proper organization of tissues and the establishment of cellular microenvironments. Laminin γ-1 is encoded by a gene located on chromosome 1q31 and is widely expressed in tissues that produce basement membranes, highlighting its importance in both normal physiology and potential pathological conditions. Anti-Laminin γ-1 antibody (3E10) serves as an invaluable tool for researchers studying the dynamics of basement membrane formation and its implications in various diseases.

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Laminin γ-1 Antibody (3E10) References:

1. Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain.  |  Kammerer, RA., et al. 1999. EMBO J. 18: 6762-70. PMID: 10581249
2. The critical role of basement membrane-independent laminin gamma 1 chain during axon regeneration in the CNS.  |  Grimpe, B., et al. 2002. J Neurosci. 22: 3144-60. PMID: 11943817
3. Schwann cell-specific ablation of laminin gamma1 causes apoptosis and prevents proliferation.  |  Yu, WM., et al. 2005. J Neurosci. 25: 4463-72. PMID: 15872093
4. Laminin-γ1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons.  |  Santos, TG., et al. 2013. J Neurochem. 124: 210-23. PMID: 23145988
5. N-linked glycosylation on laminin γ1 influences recognition of anti-laminin γ1 pemphigoid autoantibodies.  |  Li, X., et al. 2015. J Dermatol Sci. 77: 125-9. PMID: 25600662
6. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.  |  Fleger-Weckmann, A., et al. 2016. Matrix Biol. 56: 42-56. PMID: 27234308
7. Anti-p200/laminin γ1 pemphigoid associated with metastatic oesophageal cancer.  |  Goetze, S., et al. 2017. J Eur Acad Dermatol Venereol. 31: e219-e221. PMID: 27684497
8. Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.  |  Kiyozumi, D., et al. 2018. Life Sci Alliance. 1: e201800064. PMID: 30456378
9. Linear immunoglobulin A/immunoglobulin G bullous dermatosis with autoantibodies to LAD-1 and laminin-γ1.  |  Matsudate, Y., et al. 2019. Clin Exp Dermatol. 44: e44-e46. PMID: 30693555
10. Expression of laminin gamma 1 cultured hepatocytes involves repeated CTC and GC elements in the LAMC1 promoter.  |  Levavasseur, F., et al. 1996. Biochem J. 313 (Pt 3): 745-52. PMID: 8611150

The preferred Laminin γ-1 antibody is Laminin γ-1 Antibody (B-4): sc-13144.