Laminin β-2 Antibody (22): sc-135967

Laminin β-2 Antibody (22) is a mouse monoclonal IgG1 antibody that detects Laminin β-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Laminin β-2 is a vital component of the extracellular matrix, specifically within the basal lamina, where Laminin β-2 plays a significant role in maintaining tissue integrity and facilitating cell adhesion. Anti-Laminin β-2 antibody (22) provides a valuable tool for studying structural organization of tissues, as Laminin β-2 provides a scaffold that supports cell attachment and influences cell behavior during development and tissue repair. Notably, Laminin β-2 is involved in cell migration, particularly during embryogenesis, where Laminin β-2 guides cells along basement membranes, ensuring proper tissue formation and polarization. Furthermore, Laminin β-2 has been implicated in cancer progression, such as melanoma, where Laminin β-2 promotes tumor cell migration along the abluminal surface of blood vessels, a process known as extra-vascular migratory metastasis. The ability of Laminin β-2 to interact with various cell surface receptors and other extracellular matrix components underscores its importance in both normal physiological processes and pathological conditions, making anti-Laminin β-2 antibody (22) an essential tool for researchers studying cell migration, tissue development, and cancer biology.

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Laminin β-2 Antibody (22) References:

1. The lack of extracellular laminin beta2 chain deposition correlates to the loss of conjunctival epithelial keratin K4 localization in culture.  |  Kurpakus, MA. and Lin, L. 1999. Curr Eye Res. 18: 28-38. PMID: 10075200
2. Expression of laminin beta2 chain in normal human bone marrow.  |  Vogel, W., et al. 1999. Blood. 94: 1143-5. PMID: 10454804
3. Disruption of laminin beta2 chain production causes alterations in morphology and function in the CNS.  |  Libby, RT., et al. 1999. J Neurosci. 19: 9399-411. PMID: 10531444
4. Regulation of laminin beta2 chain gene expression in human cancer cell lines.  |  Durkin, ME., et al. 2001. Eur J Biochem. 268: 3797-806. PMID: 11432748
5. Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.  |  Zenker, M., et al. 2004. Hum Mol Genet. 13: 2625-32. PMID: 15367484
6. Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT1 receptor.  |  Altraja, S., et al. 2008. Respir Res. 9: 44. PMID: 18503712
7. Defective formation of the inner limiting membrane in laminin beta2- and gamma3-null mice produces retinal dysplasia.  |  Pinzón-Duarte, G., et al. 2010. Invest Ophthalmol Vis Sci. 51: 1773-82. PMID: 19907020
8. Laminin β2 gene missense mutation produces endoplasmic reticulum stress in podocytes.  |  Chen, YM., et al. 2013. J Am Soc Nephrol. 24: 1223-33. PMID: 23723427
9. Structural organization of the human and mouse laminin beta2 chain genes, and alternative splicing at the 5' end of the human transcript.  |  Durkin, ME., et al. 1996. J Biol Chem. 271: 13407-16. PMID: 8662701
10. Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae.  |  Libby, RT., et al. 1997. J Comp Neurol. 389: 655-67. PMID: 9421145

The preferred Laminin β-2 antibody is Laminin β-2 Antibody (C4): sc-59980.