Laminin β-1 Antibody (LT3): sc-33709
- Laminin β-1 Antibody (LT3) is a rat monoclonal IgG1, cited in 11 publications, provided at 200 µg/ml
- raised against partially purified preparation of laminin from the EHS mouse tumor
- Anti-Laminin beta-1 Antibody (LT3) is recommended for detection of Laminin β-1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-Laminin beta-1 Antibody (LT3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Laminin β-1 Antibody (LT3). This work is in progress.
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Laminin β-1 Antibody (LT3) is a rat monoclonal IgG1 antibody that detects Laminin β-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Laminin β-1 antibody (LT3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Laminin β-1 plays a crucial role in the formation and maintenance of basement membranes, which are specialized extracellular matrices that provide structural support to tissues and influence cellular behaviors such as proliferation, migration, and differentiation. These basement membranes are composed of laminins, which are heterotrimeric proteins made up of α, β, and γ chains, and they interact with various cell surface receptors, including integrins and dystroglycan, to mediate cell adhesion and signaling. The proper assembly and function of basement membranes are vital for tissue integrity and repair, as they serve as a barrier and scaffold for cells. The human Laminin β-1 gene is located on chromosome 7q22 and is expressed in a wide range of tissues, highlighting its importance in both normal physiology and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Laminin β-1 Antibody (LT3) References:
- Role of laminin isoforms in glomerular structure. | Hansen, K. and Abrass, CK. 1999. Pathobiology. 67: 84-91. PMID: 10023136
- Form and function: the laminin family of heterotrimers. | Colognato, H. and Yurchenco, PD. 2000. Dev Dyn. 218: 213-34. PMID: 10842354
- Transcriptional regulation of laminin gene expression. | Aberdam, D., et al. 2000. Microsc Res Tech. 51: 228-37. PMID: 11054873
- Laminin-β1 impairs spatial learning through inhibition of ERK/MAPK and SGK1 signaling. | Yang, YC., et al. 2011. Neuropsychopharmacology. 36: 2571-86. PMID: 21849984
- Crystal structures of the network-forming short-arm tips of the laminin β1 and γ1 chains. | Carafoli, F., et al. 2012. PLoS One. 7: e42473. PMID: 22860131
- Phosphorylation mapping of Laminin β1-chain: Kinases in association with active sites. | Verrou, KM., et al. 2019. J Biosci. 44: PMID: 31180068
- CRISPR-Cas9-mediated labelling of the C-terminus of human laminin β1 leads to secretion inhibition. | Shaw, L., et al. 2020. BMC Res Notes. 13: 90. PMID: 32085798
- The laminin family. | Tryggvason, K. 1993. Curr Opin Cell Biol. 5: 877-82. PMID: 8240830
- Role of laminin in endothelial cell recognition and differentiation. | Schnaper, HW., et al. 1993. Kidney Int. 43: 20-5. PMID: 8433560
- Domains of laminin. | Engvall, E. and Wewer, UM. 1996. J Cell Biochem. 61: 493-501. PMID: 8806072
- Laminin and the mechanism of neuronal outgrowth. | Luckenbill-Edds, L. 1997. Brain Res Brain Res Rev. 23: 1-27. PMID: 9063584
- Laminin isoforms and epithelial development. | Ekblom, M., et al. 1998. Ann N Y Acad Sci. 857: 194-211. PMID: 9917842
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin β-1 Antibody (LT3) | sc-33709 | 200 µg/ml | $322.00 | |||
Laminin β-1 Antibody (LT3) AC | sc-33709 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Laminin β-1 Antibody (LT3) HRP | sc-33709 HRP | 200 µg/ml | $322.00 | |||
Laminin β-1 Antibody (LT3) FITC | sc-33709 FITC | 200 µg/ml | $336.00 | |||
Laminin β-1 Antibody (LT3) PE | sc-33709 PE | 200 µg/ml | $349.00 | |||
Laminin β-1 Antibody (LT3) Alexa Fluor® 488 | sc-33709 AF488 | 200 µg/ml | $364.00 | |||
Laminin β-1 Antibody (LT3) Alexa Fluor® 546 | sc-33709 AF546 | 200 µg/ml | $364.00 | |||
Laminin β-1 Antibody (LT3) Alexa Fluor® 594 | sc-33709 AF594 | 200 µg/ml | $364.00 | |||
Laminin β-1 Antibody (LT3) Alexa Fluor® 647 | sc-33709 AF647 | 200 µg/ml | $364.00 | |||
Laminin β-1 Antibody (LT3) Alexa Fluor® 680 | sc-33709 AF680 | 200 µg/ml | $364.00 | |||
Laminin β-1 Antibody (LT3) Alexa Fluor® 790 | sc-33709 AF790 | 200 µg/ml | $364.00 |