Laminin β-1 Antibody (3A4): sc-65644

Laminin β-1 Antibody (3A4) is a rat monoclonal IgG2a antibody that detects Laminin β-1 in mouse tissues through applications such as immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Laminin β-1 antibody (3A4) plays a crucial role in studying basement membranes, which are specialized extracellular matrices providing structural support to various tissues. These membranes regulate cell behavior, influencing processes such as proliferation, migration, and differentiation, thereby impacting overall tissue architecture and function. Laminin β-1 exists as a heterotrimer composed of α, β, and γ chain subunits, which allows self-assembly and interaction with other matrix components, including type IV collagen and proteoglycans. This unique structure enables Laminin β-1 to mediate cell adhesion and signaling through interactions with integrins and other receptors, making Laminin β-1 vital for maintaining tissue integrity and facilitating communication between cells and their extracellular environment. Located on chromosome 7q22, the human Laminin β-1 gene is widely expressed in tissues that produce basement membranes, underscoring Laminin β-1′s importance in various physiological and pathological processes. Laminin β-1 monoclonal antibody (3A4) serves as an invaluable tool for researchers studying the dynamics of basement membranes and their role in health and disease.

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Laminin β-1 Antibody (3A4) References:

1. Decreased expression of laminin beta 1 in chromosome 21-linked Bethlem myopathy.  |  Merlini, L., et al. 1999. Neuromuscul Disord. 9: 326-9. PMID: 10407855
2. Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin beta1 and gamma1 chains.  |  Geberhiwot, T., et al. 2000. Matrix Biol. 19: 163-7. PMID: 10842099
3. Domain IV of mouse laminin beta1 and beta2 chains.  |  Sasaki, T., et al. 2002. Eur J Biochem. 269: 431-42. PMID: 11856301
4. Tissue distribution of the laminin beta1 and beta2 chain during embryonic and fetal human development.  |  Roediger, M., et al. 2010. J Mol Histol. 41: 177-84. PMID: 20552257
5. The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma.  |  Dekkers, BG., et al. 2010. Respir Res. 11: 170. PMID: 21129174
6. Expression of laminin β1 and integrin α2 in the anterior temporal neocortex tissue of patients with intractable epilepsy.  |  Wu, Y., et al. 2011. Int J Neurosci. 121: 323-8. PMID: 21370991
7. Forced expression of laminin beta1 in podocytes prevents nephrotic syndrome in mice lacking laminin beta2, a model for Pierson syndrome.  |  Suh, JH., et al. 2011. Proc Natl Acad Sci U S A. 108: 15348-53. PMID: 21876163
8. Pathogenic mechanisms in lupus nephritis: Nucleosomes bind aberrant laminin β1 with high affinity and colocalize in the electron-dense deposits.  |  Olin, AI., et al. 2014. Arthritis Rheumatol. 66: 397-406. PMID: 24504812
9. Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity.  |  Shen, J., et al. 1997. Cell Growth Differ. 8: 1297-304. PMID: 9419418
10. Sequences 5' of the basement membrane laminin beta 1 chain gene (LAMB1) direct the expression of beta-galactosidase during development of the mouse testis and ovary.  |  Li, C. and Gudas, LJ. 1997. Differentiation. 62: 129-37. PMID: 9447707

The preferred Laminin β-1 antibody is Laminin β-1 Antibody (LT3): sc-33709.