Laminin α-4 Antibody (3H2): sc-130540

Laminin α-4 Antibody (3H2) is a mouse monoclonal IgG1 antibody that detects Laminin α-4 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Laminin α-4 is a crucial component of basement membranes, which are specialized extracellular matrices that provide structural support and influence cellular behavior. These membranes are vital for maintaining tissue integrity and facilitating communication between cells, as they are involved in processes such as cell adhesion, migration, and differentiation. The unique structure of Laminin α-4, which consists of a heterotrimeric assembly of α, β, and γ chains, allows for interaction with various cell surface receptors, including integrins and dystroglycan, thereby playing a significant role in cellular signaling pathways. Proper functioning of Laminin α-4 is essential for the development and maintenance of tissues, particularly in organs such as the heart, lungs, and intestines, where Laminin α-4 contributes to the regulation of cell proliferation and tissue architecture. The human Laminin α-4 gene is located on chromosome 6q21, and Laminin α-4 expression is critical for the formation of functional basement membranes, underscoring the importance of anti-Laminin α-4 antibody (3H2) in research and diagnostic applications related to tissue health and disease.

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Laminin α-4 Antibody (3H2) References:

1. Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo.  |  Gonzalez, AM., et al. 2002. Proc Natl Acad Sci U S A. 99: 16075-80. PMID: 12454288
2. Localization of the laminin alpha4 chain in the skin and identification of a heparin-dependent cell adhesion site within the laminin alpha4 chain C-terminal LG4 module.  |  Matsuura, H., et al. 2004. J Invest Dermatol. 122: 614-20. PMID: 15086543
3. Regulation of MMP3 by laminin alpha 4 in human osteoarthritic cartilage.  |  Fuerst, FC., et al. 2011. Scand J Rheumatol. 40: 494-6. PMID: 22150225
4. Laminin α4 contributes to airway remodeling and inflammation in asthma.  |  Prabhala, P., et al. 2019. Am J Physiol Lung Cell Mol Physiol. 317: L768-L777. PMID: 31553662
5. SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4.  |  Carmona-Rodríguez, L., et al. 2020. Oncoimmunology. 9: 1794163. PMID: 32934887
6. Laminin alpha 4 promotes bone regeneration by facilitating cell adhesion and vascularization.  |  Tang, Y., et al. 2021. Acta Biomater. 126: 183-198. PMID: 33711525
7. Laminin-α4 Is Upregulated in Both Human and Murine Models of Obesity.  |  Goddi, A., et al. 2021. Front Endocrinol (Lausanne). 12: 698621. PMID: 34394003
8. Primary structure and expression of a novel human laminin alpha 4 chain.  |  Iivanainen, A., et al. 1995. FEBS Lett. 365: 183-8. PMID: 7781776
9. The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains.  |  Richards, A., et al. 1996. Eur J Biochem. 238: 813-21. PMID: 8706685
10. The complete cDNA coding sequence and tissue-specific expression of the mouse laminin alpha 4 chain.  |  Liu, J. and Mayne, R. 1996. Matrix Biol. 15: 433-7. PMID: 9049981

The preferred Laminin α-4 antibody is Laminin α-4 Antibody (6C3): sc-130541.