Laminin α-4 Antibody (6C3): sc-130541

Laminin α-4 Antibody (6C3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Laminin α-4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Laminin α-4 antibody (6C3) is available as a non-conjugated format. Laminin α-4 is a crucial component of the extracellular matrix, specifically within basement membranes, which play a vital role in tissue architecture and cellular functions. Laminin α-4 exists as a heterotrimer composed of α, β, and γ chain subunits, and proper assembly and function are essential for maintaining the structural integrity of tissues. Laminin α-4 interacts with various cell surface receptors, including integrins and dystroglycan, facilitating cell adhesion, migration, and signaling. This interaction is particularly important in processes such as wound healing and tissue repair, where the extracellular matrix provides not only structural support but also biochemical signals that influence cell behavior. The human Laminin α-4 gene is located on chromosome 6q21 and is expressed in several tissues, including the heart, lung, ovary, and intestines, highlighting its significance in both normal physiology and potential pathological conditions.

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Laminin α-4 Antibody (6C3) References:

1. Role of laminin isoforms in glomerular structure.  |  Hansen, K. and Abrass, CK. 1999. Pathobiology. 67: 84-91. PMID: 10023136
2. Form and function: the laminin family of heterotrimers.  |  Colognato, H. and Yurchenco, PD. 2000. Dev Dyn. 218: 213-34. PMID: 10842354
3. Transcriptional regulation of laminin gene expression.  |  Aberdam, D., et al. 2000. Microsc Res Tech. 51: 228-37. PMID: 11054873
4. Downregulation of laminin alpha4 chain expression inhibits glioma invasion in vitro and in vivo.  |  Nagato, S., et al. 2005. Int J Cancer. 117: 41-50. PMID: 15915502
5. Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.  |  Takkunen, M., et al. 2008. Histochem Cell Biol. 130: 509-25. PMID: 18496706
6. Monoclonal antibodies to human laminin α4 chain globular domain inhibit tumor cell adhesion and migration on laminins 411 and 421, and binding of α6β1 integrin and MCAM to α4-laminins.  |  Ishikawa, T., et al. 2014. Matrix Biol. 36: 5-14. PMID: 24681327
7. Primary structure and expression of a novel human laminin alpha 4 chain.  |  Iivanainen, A., et al. 1995. FEBS Lett. 365: 183-8. PMID: 7781776
8. The laminin family.  |  Tryggvason, K. 1993. Curr Opin Cell Biol. 5: 877-82. PMID: 8240830
9. Role of laminin in endothelial cell recognition and differentiation.  |  Schnaper, HW., et al. 1993. Kidney Int. 43: 20-5. PMID: 8433560
10. Domains of laminin.  |  Engvall, E. and Wewer, UM. 1996. J Cell Biochem. 61: 493-501. PMID: 8806072
11. Laminin and the mechanism of neuronal outgrowth.  |  Luckenbill-Edds, L. 1997. Brain Res Brain Res Rev. 23: 1-27. PMID: 9063584
12. Laminin isoforms and epithelial development.  |  Ekblom, M., et al. 1998. Ann N Y Acad Sci. 857: 194-211. PMID: 9917842

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Laminin α-4 Antibody (6C3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Laminin α-4 Antibody (6C3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Laminin α-4 Antibody (6C3) Specifications

Alternate Product Name: Laminin α-4

Product Clone Name: 6C3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Laminin α4β1γ1

Epitope Species: human

Product Reactivity/Detection: Laminin α-4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Laminin α-4 Antibody (6C3): N/A