Laminin α-1 Antibody (E3-1): sc-65645
- Laminin α-1 Antibody (E3-1) is a rat monoclonal IgG2a, cited in 2 publications, provided at 200 µg/ml
- raised against the E3 fragment of Laminin α-1 of mouse origin, with epitope mapping to the Globular domains G4-5
- recommended for detection of Laminin α-1 of mouse origin by IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Laminin α-1 Antibody (E3-1). This work is in progress.
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SEE ALSO...
Laminin α-1 Antibody (E3-1) is a rat monoclonal IgG2a antibody that detects Laminin α-1 in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Laminin α-1 is a crucial component of basement membranes, which are specialized extracellular matrices that provide structural support and influence various cellular functions. These membranes are essential for maintaining tissue integrity and play a significant role in processes such as cell proliferation, migration, and differentiation. The unique structure of Laminin α-1, which consists of a heterotrimer formed by α, β, and γ chain subunits, allows for self-assembly and interaction with other matrix components, facilitating the formation of stable basement membranes. This structural versatility is vital for the proper organization of tissues and the regulation of cellular behavior. The human Laminin α-1 gene is located on chromosome 18p11.3 and shows over-expression in the frontal cortex of individuals with Alzheimer′s disease, highlighting potential involvement in neurodegenerative conditions. Anti-Laminin α-1 antibody (E3-1) serves as an invaluable tool for researchers studying the dynamics of basement membranes and their implications in health and disease.
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Laminin α-1 Antibody (E3-1) References:
- Identification of metastasis-promoting sequences in the mouse laminin alpha 1 chain. | Kuratomi, Y., et al. 1999. Exp Cell Res. 249: 386-95. PMID: 10366438
- Laminin {alpha}1 chain corrects male infertility caused by absence of laminin {alpha}2 chain. | Häger, M., et al. 2005. Am J Pathol. 167: 823-33. PMID: 16127160
- Functional sites in the laminin alpha chains. | Suzuki, N., et al. 2005. Connect Tissue Res. 46: 142-52. PMID: 16147852
- The laminin alpha-1 chain derived peptide, AG73, increases fibronectin levels in breast and melanoma cancer cells. | Engbring, JA., et al. 2008. Clin Exp Metastasis. 25: 241-52. PMID: 18185912
- Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction. | Patel, TR., et al. 2016. Matrix Biol. 49: 93-105. PMID: 26215696
- Loss of laminin alpha 1 results in multiple structural defects and divergent effects on adhesion during vertebrate optic cup morphogenesis. | Bryan, CD., et al. 2016. Dev Biol. 416: 324-37. PMID: 27339294
- Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation. | De Arcangelis, A., et al. 1996. J Cell Biol. 133: 417-30. PMID: 8609173
- Expression of laminin alpha 1, alpha 5 and beta 2 chains during embryogenesis of the kidney and vasculature. | Durbeej, M., et al. 1996. Matrix Biol. 15: 397-413. PMID: 9049978
- Genetics of laminin alpha 2 chain (or merosin) deficient congenital muscular dystrophy: from identification of mutations to prenatal diagnosis. | Guicheney, P., et al. 1997. Neuromuscul Disord. 7: 180-6. PMID: 9185182
- Laminin alpha 1, alpha 2, alpha 4 and beta 1 chain mRNA expression in mouse embryonic, neonatal, and adult hearts. | Hirohata, S., et al. 1997. Jpn Heart J. 38: 281-9. PMID: 9201115
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin α-1 Antibody (E3-1) | sc-65645 | 200 µg/ml | $316.00 |