Lamin A/C Antibody (346): sc-7293

Lamin A/C Antibody (346) is a mouse monoclonal IgM kappa light chain antibody that detects Lamin A and Lamin C from mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Lamin A/C antibody (346) is available in both conjugated and non-conjugated forms, providing versatility for various experimental needs. Lamin A and C are essential components of the nuclear lamina, a dense fibrillar network inside the nucleus that plays a crucial role in maintaining nuclear structure and regulating gene expression. The integrity of the nuclear envelope is vital for cellular function, as this structure protects genetic material and facilitates chromatin organization. Lamin A undergoes post-translational modifications, including phosphorylation and farnesylation, which influence protein interactions and cellular processes such as apoptosis and differentiation. Specific proteases like Mch2 cleave Lamin A during apoptosis, highlighting Lamin A′s importance in cellular longevity and cell death pathway regulation. Understanding Lamin A and C dynamics, along with nuclear protein interactions, remains essential for elucidating roles in health and disease, particularly in laminopathies, where protein mutations can lead to severe cellular dysfunction.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Lamin A/C Antibody (346) has 147 citations in a variety of scientific publications.

Primary antibodies like Anti-Lamin A/C Antibody (346) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Lamin A/C Antibody (346) Specifications

Alternate Product Name: Lamin A/C

Product Clone Name: 346

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Lamin A/C

Epitope Species: rat

Product Reactivity/Detection: Lamin A and Lamin C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 147 citations in various scientific publications

Available Conjugates/Forms for Lamin A/C Antibody (346): AC: Agarose

The preferred Lamin A/C antibody is Lamin A/C Antibody (636): sc-7292.