lactoferrin Antibody (B97): sc-53498
- lactoferrin Antibody (B97) is a mouse monoclonal IgG1 κ lactoferrin antibody, cited in 5 publications, provided at 200 µg/ml
- raised against full length purified human lactoferrin
- lactoferrin Antibody (B97) is recommended for detection of lactoferrin of human origin by WB, IP, IF, IHC(P), FCM and ELISA
- Anti-lactoferrin Antibody (B97) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for lactoferrin Antibody (B97) for WB and IHC(P) applications. These reagents are now offered in bundles with lactoferrin Antibody (B97) (see ordering information below).
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Lactoferrin Antibody (B97) is a mouse monoclonal IgG1 kappa light chain antibody that detects human lactoferrin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-lactoferrin antibody (B97) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Lactoferrin, a member of the transferrin family, plays a crucial role in iron metabolism by binding iron and regulating its availability, which is essential for various biological processes, including immune response and cellular growth. Lactoferrin is predominantly found in milk, tears, and leukocytes, where lactoferrin not only serves as an iron-binding protein but also exhibits antimicrobial properties. Lactoferrin′s ability to degrade the IgA1 protease secreted by Haemophilus influenzae enhances the effectiveness of the human IgA1 antibody in preventing bacterial colonization. Lactoferrin has been shown to inhibit HIV-1 replication by interfering with viral fusion and entry into host cells, highlighting potential therapeutic applications. The gene encoding human lactoferrin is located on chromosome 3p21.31, and lactoferrin expression is regulated in response to various physiological and pathological conditions, making lactoferrin a significant biomarker in immunological studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
lactoferrin Antibody (B97) References:
- Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria. | Nibbering, PH., et al. 2001. Infect Immun. 69: 1469-76. PMID: 11179314
- A milk protein lactoferrin enhances human T cell leukemia virus type I and suppresses HIV-1 infection. | Moriuchi, M. and Moriuchi, H. 2001. J Immunol. 166: 4231-6. PMID: 11238676
- Lactoferrin regulates proliferative response of human peripheral blood mononuclear cells to phytohemagglutinin and mixed lymphocyte reaction. | Zimecki, M., et al. 2001. Arch Immunol Ther Exp (Warsz). 49: 147-54. PMID: 11348019
- Lactoferrin and host defense. | Ward, PP., et al. 2002. Biochem Cell Biol. 80: 95-102. PMID: 11908649
- Lactoferrin in Aseptic and Septic Inflammation. | Lepanto, MS., et al. 2019. Molecules. 24: PMID: 30987256
- Targeting cancer with lactoferrin nanoparticles: recent advances. | Kondapi, AK. 2020. Nanomedicine (Lond). 15: 2071-2083. PMID: 32779524
- Lactoferrin and hematoma detoxification after intracerebral hemorrhage. | Zhao, X., et al. 2021. Biochem Cell Biol. 99: 97-101. PMID: 32886889
- Factors affecting human milk lactoferrin. | Briana, DD. and Papaevangelou, V. 2022. J Matern Fetal Neonatal Med. 35: 8111. PMID: 34362273
- Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. | Teng, CT., et al. 1987. Somat Cell Mol Genet. 13: 689-93. PMID: 3478818
- Biomedical Applications of Lactoferrin on the Ocular Surface. | Regueiro, U., et al. 2023. Pharmaceutics. 15: PMID: 36986726
- Iron transport and storage proteins. | Aisen, P. and Listowsky, I. 1980. Annu Rev Biochem. 49: 357-93. PMID: 6996567
- A monoclonal antibody-based immunoassay for human lactoferrin. | Chung, S., et al. 1985. J Immunol Methods. 84: 135-41. PMID: 2415634
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
lactoferrin Antibody (B97) | sc-53498 | 200 µg/ml | $322.00 | |||
lactoferrin Antibody (B97): m-IgG Fc BP-HRP Bundle | sc-526820 | 200 µg Ab; 10 µg BP | $361.00 | |||
lactoferrin Antibody (B97): m-IgG1 BP-HRP Bundle | sc-532193 | 200 µg Ab; 20 µg BP | $361.00 | |||
lactoferrin Antibody (B97) AC | sc-53498 AC | 500 µg/ml, 25% agarose | $424.00 | |||
lactoferrin Antibody (B97) HRP | sc-53498 HRP | 200 µg/ml | $322.00 | |||
lactoferrin Antibody (B97) FITC | sc-53498 FITC | 200 µg/ml | $336.00 | |||
lactoferrin Antibody (B97) PE | sc-53498 PE | 200 µg/ml | $349.00 | |||
lactoferrin Antibody (B97) Alexa Fluor® 488 | sc-53498 AF488 | 200 µg/ml | $364.00 | |||
lactoferrin Antibody (B97) Alexa Fluor® 546 | sc-53498 AF546 | 200 µg/ml | $364.00 | |||
lactoferrin Antibody (B97) Alexa Fluor® 594 | sc-53498 AF594 | 200 µg/ml | $364.00 | |||
lactoferrin Antibody (B97) Alexa Fluor® 647 | sc-53498 AF647 | 200 µg/ml | $364.00 | |||
lactoferrin Antibody (B97) Alexa Fluor® 680 | sc-53498 AF680 | 200 µg/ml | $364.00 | |||
lactoferrin Antibody (B97) Alexa Fluor® 790 | sc-53498 AF790 | 200 µg/ml | $364.00 |