LACE1 Antibody (C-3): sc-514632

LACE1 Antibody (C-3) is a mouse monoclonal IgM antibody that detects LACE1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LACE1 antibody (C-3) is available as the non-conjugated form. LACE1, or Lactation Elevated Protein 1, is a 481 amino acid protein that plays a crucial role in cellular processes, particularly in regulating mitochondrial function and energy metabolism. LACE1 is part of the AFG1 ATPase family, which is essential for maintaining mitochondrial integrity and function. Disruptions in mitochondrial processes can lead to various diseases, including neurodegenerative disorders and metabolic syndromes. LACE1 is encoded by a gene located on human chromosome 6, a region harboring approximately 1,200 genes implicated in various genetic conditions, including certain cancers and autoimmune diseases. LACE1 may also interact with other proteins involved in mitochondrial dynamics, further underscoring its importance in cellular health and disease.

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LACE1 Antibody (C-3) References:

1. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.  |  Cesari, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 5956-61. PMID: 12719539
2. The DNA sequence and analysis of human chromosome 6.  |  Mungall, AJ., et al. 2003. Nature. 425: 805-11. PMID: 14574404
3. Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22.  |  Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
4. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.  |  Fan, J., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 29-37. PMID: 19308960
5. Associations among behavior-related susceptibility factors in porphyria cutanea tarda.  |  Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
6. A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene.  |  Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LACE1 Antibody (C-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LACE1 Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LACE1 Antibody (C-3) Specifications

Alternate Product Name: LACE1

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 424-442

Epitope Target: LACE1

Epitope Species: human

Product Reactivity/Detection: LACE1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LACE1 Antibody (C-3): P: Blocking Peptide