LACC1 Antibody (E-12): sc-376231

LACC1 Antibody (E-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects LACC1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LACC1 antibody (E-12) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LACC1 is a 430 amino acid protein encoded by a gene located on chromosome 13, which is significant due to its association with several key tumor suppressor genes, including BRCA2 and RB1. RB1 gene encodes a vital tumor suppressor protein that plays a crucial role in regulating cell cycle; when mutated, RB1 can lead to uncontrolled cell proliferation and various cancers, including retinoblastoma. LACC1′s presence in cellular processes suggests potential involvement in tumor suppression, making LACC1 an important target for cancer research. Chromosome 13 harbors genes that, when altered, can lead to severe developmental disorders, such as trisomy 13, which is associated with significant morbidity. LACC1 gene product has been provisionally designated pending further characterization, highlighting the need for continued research into biological functions and implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LACC1 Antibody (E-12) References:

1. The DNA sequence and analysis of human chromosome 13.  |  Dunham, A., et al. 2004. Nature. 428: 522-8. PMID: 15057823
2. A new gene for Tourette's syndrome: a window into causal mechanisms?  |  Grados, MA. and Walkup, JT. 2006. Trends Genet. 22: 291-3. PMID: 16678301
3. Non-disjunction of chromosome 13.  |  Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
4. Variable expressivity in Patau syndrome is not all related to trisomy 13 mosaicism.  |  Hsu, HF. and Hou, JW. 2007. Am J Med Genet A. 143A: 1739-48. PMID: 17603803
5. The origin of trisomy 13.  |  Hall, HE., et al. 2007. Am J Med Genet A. 143A: 2242-8. PMID: 17853475
6. Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.  |  Hassler, M., et al. 2007. Mol Cell. 28: 371-85. PMID: 17996702
7. BRCA2: a universal recombinase regulator.  |  Thorslund, T. and West, SC. 2007. Oncogene. 26: 7720-30. PMID: 18066084
8. Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two children with systemic and extended oligoarticular course.  |  Kallinich, T., et al. 2016. Pediatr Rheumatol Online J. 14: 63. PMID: 27881174
9. LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.  |  Wei, Z., et al. 2022. Nature. 609: 348-353. PMID: 35978195
10. Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function.  |  Li, Y., et al. 2025. Nat Commun. 16: 2577. PMID: 40089498
11. RB and cell cycle progression.  |  Giacinti, C. and Giordano, A. 2006. Oncogene. 25: 5220-7. PMID: 16936740
12. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome.  |  Deng, H., et al. 2006. Acta Neurol Scand. 114: 400-2. PMID: 17083340

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LACC1 Antibody (E-12) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-LACC1 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LACC1 Antibody (E-12) Specifications

Alternate Product Name: LACC1

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 185-430

Epitope Target: LACC1

Epitope Species: human

Product Reactivity/Detection: LACC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for LACC1 Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin