L-type Ca⁺⁺ CP α1D Antibody (E-3): sc-515679

L-type Ca++ CP α1D Antibody (E-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects L-type Ca++ CP α1D in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). L-type Ca++ CP α1D (E-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. L-type calcium channels play a crucial role in mediating calcium entry into excitable cells, essential for processes such as muscle contraction, hormone release, and neurotransmitter secretion. Structurally, L-type calcium channels are complex, multimeric assemblies composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide-linked alpha-2/delta subunit, and a transmembrane gamma subunit. This intricate structure allows for precise regulation of calcium ion flow, critical for initiating muscle contractions and endocrine functions. L-type calcium channels form macromolecular signaling complexes with G protein-coupled receptors, enhancing calcium signaling pathway specificity and influencing various physiological responses. Diverse biophysical and pharmacological properties of L-type calcium currents underscore L-type Ca++ CP α1D′s importance in cellular signaling and function, making anti-L-type Ca++ CP α1D antibody (E-3) an invaluable research tool for studying calcium signaling mechanisms.

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L-type Ca⁺⁺ CP α1D Antibody (E-3) References:

1. Structure and regulation of voltage-gated Ca2+ channels.  |  Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
2. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.  |  Davare, MA., et al. 2001. Science. 293: 98-101. PMID: 11441182
3. Impact of gating modulation in CaV1.3 L-type calcium channels.  |  Koschak, A. 2010. Channels (Austin). 4: 523-5. PMID: 21150316
4. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.  |  Kang, S., et al. 2012. Nat Commun. 3: 1146. PMID: 23093183
5. The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.  |  Berger, SM. and Bartsch, D. 2014. Cell Tissue Res. 357: 463-76. PMID: 24996399
6. Regulation of Postsynaptic Stability by the L-type Calcium Channel CaV1.3 and its Interaction with PDZ Proteins.  |  Stanika, RI., et al. 2015. Curr Mol Pharmacol. 8: 95-101. PMID: 25966696
7. Cav1.2 and Cav1.3 L-type calcium channels independently control short- and long-term sensitization to pain.  |  Radwani, H., et al. 2016. J Physiol. 594: 6607-6626. PMID: 27231046
8. Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond.  |  Mesirca, P., et al. 2016. J Physiol. 594: 5869-5879. PMID: 27374078
9. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice.  |  Ortner, NJ., et al. 2023. JCI Insight. 8: PMID: 37698939
10. The L-type calcium channel CaV1.3: A potential target for cancer therapy.  |  Liu, X., et al. 2024. J Cell Mol Med. 28: e70123. PMID: 39365143
11. Molecular biology of calcium channels.  |  Perez-Reyes, E. and Schneider, T. 1995. Kidney Int. 48: 1111-24. PMID: 8569073
12. The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?  |  Randall, AD. 1998. J Membr Biol. 161: 207-13. PMID: 9493126

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-L-type Ca⁺⁺ CP α1D Antibody (E-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-L-type Ca⁺⁺ CP α1D Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

L-type Ca⁺⁺ CP α1D Antibody (E-3) Specifications

Alternate Product Name: L-type Ca++ CP α1D

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 2018-2042

Epitope Target: L-type Ca⁺⁺ CP α1D

Epitope Species: human

Product Reactivity/Detection: L-type Ca⁺⁺ CP α1D

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for L-type Ca⁺⁺ CP α1D Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin