L-FABP Antibody (C-4): sc-374537
- L-FABP Antibody (C-4) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 7-126 mapping within an internal region of L-FABP of human origin
- Anti-L-FABP Antibody (C-4) is recommended for detection of L-FABP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-L-FABP Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for L-FABP Antibody (C-4) for WB and IHC(P) applications. These reagents are now offered in bundles with L-FABP Antibody (C-4) (see ordering information below).
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L-FABP Antibody (C-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects L-FABP in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-L-FABP antibody (C-4) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. L-FABP, or liver fatty acid-binding protein, is crucial for the intracellular transport of long-chain fatty acids and plays a significant role in lipid metabolism, particularly in the liver. L-FABP is predominantly located in the cytoplasm of liver cells, where L-FABP facilitates the uptake and transport of fatty acids, thereby influencing energy homeostasis and lipid storage. Proper functioning of L-FABP is essential for maintaining metabolic balance, as L-FABP helps regulate the availability of fatty acids for energy production and storage, which is particularly important in conditions such as obesity and diabetes. L-FABP expression is modulated by various factors, including hormonal changes and dietary intake, highlighting L-FABP′s role in adapting to metabolic demands.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
L-FABP Antibody (C-4) References:
- The fatty acid transport function of fatty acid-binding proteins. | Storch, J. and Thumser, AE. 2000. Biochim Biophys Acta. 1486: 28-44. PMID: 10856711
- Unravelling the significance of cellular fatty acid-binding proteins. | Glatz, JF. and Storch, J. 2001. Curr Opin Lipidol. 12: 267-74. PMID: 11353329
- Fatty acid-binding proteins of nervous tissue. | Veerkamp, JH. and Zimmerman, AW. 2001. J Mol Neurosci. 16: 133-42; discussion 151-7. PMID: 11478368
- Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. | Smathers, RL., et al. 2012. PLoS One. 7: e38459. PMID: 22701647
- Impact of L-FABP and glucose on polyunsaturated fatty acid induction of PPARα-regulated β-oxidative enzymes. | Petrescu, AD., et al. 2013. Am J Physiol Gastrointest Liver Physiol. 304: G241-56. PMID: 23238934
- Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver. | Smathers, RL., et al. 2013. J Lipid Res. 54: 1335-45. PMID: 23359610
- Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury. | Parr, SK., et al. 2015. Kidney Int. 87: 640-8. PMID: 25229339
- Rapid and ultrasensitive detection of acute kidney injury biomarkers CH3L1 and L-FABP using surface-enhanced Raman spectroscopy. | Wang, L., et al. 2023. Spectrochim Acta A Mol Biomol Spectrosc. 295: 122604. PMID: 36947940
- Cytoplasmic fatty acid-binding proteins: their structure and genes. | Veerkamp, JH. and Maatman, RG. 1995. Prog Lipid Res. 34: 17-52. PMID: 7644552
- Mechanisms of regulation of liver fatty acid-binding protein. | Kaikaus, RM., et al. Mol Cell Biochem. 123: 93-100. PMID: 8232272
- Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. | Hotamisligil, GS., et al. 1996. Science. 274: 1377-9. PMID: 8910278
- L-FABP and I-FABP expression increase NBD-stearate uptake and cytoplasmic diffusion in L cells. | Murphy, EJ. 1998. Am J Physiol. 275: G244-9. PMID: 9688651
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-FABP Antibody (C-4) | sc-374537 | 200 µg/ml | $316.00 | |||
L-FABP Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-525978 | 200 µg Ab; 10 µg BP | $354.00 | |||
L-FABP Antibody (C-4): m-IgG2a BP-HRP Bundle | sc-546474 | 200 µg Ab; 10 µg BP | $354.00 | |||
L-FABP Antibody (C-4) AC | sc-374537 AC | 500 µg/ml, 25% agarose | $416.00 | |||
L-FABP Antibody (C-4) HRP | sc-374537 HRP | 200 µg/ml | $316.00 | |||
L-FABP Antibody (C-4) FITC | sc-374537 FITC | 200 µg/ml | $330.00 | |||
L-FABP Antibody (C-4) PE | sc-374537 PE | 200 µg/ml | $343.00 | |||
L-FABP Antibody (C-4) Alexa Fluor® 488 | sc-374537 AF488 | 200 µg/ml | $357.00 | |||
L-FABP Antibody (C-4) Alexa Fluor® 546 | sc-374537 AF546 | 200 µg/ml | $357.00 | |||
L-FABP Antibody (C-4) Alexa Fluor® 594 | sc-374537 AF594 | 200 µg/ml | $357.00 | |||
L-FABP Antibody (C-4) Alexa Fluor® 647 | sc-374537 AF647 | 200 µg/ml | $357.00 | |||
L-FABP Antibody (C-4) Alexa Fluor® 680 | sc-374537 AF680 | 200 µg/ml | $357.00 | |||
L-FABP Antibody (C-4) Alexa Fluor® 790 | sc-374537 AF790 | 200 µg/ml | $357.00 |