L-FABP Activators
L-FABP Activators comprise a category of chemicals with the capability to modulate the activity of Liver Fatty Acid-Binding Protein (L-FABP) through diverse mechanisms. These compounds, exemplified by GW501516 and Rosiglitazone, operate by indirectly activating L-FABP through the targeted interaction with specific nuclear receptors known as peroxisome proliferator-activated receptors (PPARs). These PPARs play a pivotal role in the regulation of adipocyte differentiation and lipid metabolism pathways that intricately intersect with L-FABP functions. Activation of PPARs enhances lipid metabolism and facilitates the transport of fatty acids, consequently indirectly activating L-FABP.
Furthermore, there exist direct L-FABP activators, such as Oleic Acid and Linoleic Acid, which engage with L-FABP's fatty acid binding pocket directly. This interaction serves to augment the uptake and transport of fatty acids, thereby directly enhancing lipid metabolism within cellular contexts. Additionally, compounds like AICAR and AMP activate AMP-activated protein kinase (AMPK), a master regulator of cellular energy metabolism. The activation of AMPK indirectly activates L-FABP by orchestrating adjustments in cellular energy metabolism and lipid-related pathways that intimately intersect with L-FABP functions. Collectively, these L-FABP Activators provide a valuable perspective on strategies for activating L-FABP activity. Their actions encompass diverse cellular pathways and processes, contributing to a comprehensive understanding of L-FABP regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516 is a selective agonist of peroxisome proliferator-activated receptor delta (PPARδ). Activation of PPARδ can indirectly activate L-FABP by promoting lipid metabolism and fatty acid transport pathways that intersect with L-FABP functions. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a thiazolidinedione (TZD) that activates peroxisome proliferator-activated receptor gamma (PPARγ). Activation of PPARγ indirectly activates L-FABP by regulating adipocyte differentiation and lipid metabolism pathways that intersect with L-FABP functions. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643 is a synthetic agonist of peroxisome proliferator-activated receptor alpha (PPARα). Activation of PPARα indirectly activates L-FABP by influencing lipid metabolism and fatty acid transport pathways that intersect with L-FABP functions. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid is a monounsaturated fatty acid that can directly activate L-FABP by binding to its fatty acid binding pocket. This activation enhances fatty acid uptake and transport, facilitating lipid metabolism in cells. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK can indirectly activate L-FABP by modulating cellular energy metabolism and lipid-related pathways that intersect with L-FABP functions. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a pan-agonist of peroxisome proliferator-activated receptors (PPARs), including PPARα, PPARγ, and PPARδ. Activation of PPARs indirectly activates L-FABP by regulating lipid metabolism and fatty acid transport pathways that intersect with L-FABP functions. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid is a polyunsaturated fatty acid that can directly activate L-FABP by binding to its fatty acid binding pocket. This activation enhances fatty acid uptake and transport, facilitating lipid metabolism in cells. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone is another thiazolidinedione (TZD) that activates peroxisome proliferator-activated receptor gamma (PPARγ). Activation of PPARγ indirectly activates L-FABP by regulating adipocyte differentiation and lipid metabolism pathways that intersect with L-FABP functions. | ||||||
Palmitoleic acid | 373-49-9 | sc-205424 sc-205424A sc-205424B sc-205424C sc-205424D | 100 mg 500 mg 1 g 5 g 10 g | $33.00 $135.00 $238.00 $1039.00 $1907.00 | 4 | |
Palmitoleic Acid is a monounsaturated fatty acid that can directly activate L-FABP by binding to its fatty acid binding pocket. This activation enhances fatty acid uptake and transport, facilitating lipid metabolism in cells. | ||||||