KV4.2 Antibody (H-5): sc-390571

KV4.2 Antibody (H-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects KV4.2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KV4.2 antibody (H-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KV4.2 plays a crucial role in regulating neuronal excitability and action potential repolarization, which is essential for proper neuronal signaling and muscle contraction. Located in the plasma membrane, KV4.2 is part of the voltage-gated potassium channel family, which controls potassium ion flow across cell membranes. This ion flow maintains resting membrane potential and facilitates rapid repolarization of action potentials, influencing the frequency and timing of neuronal firing. KV4.2 forms functional channels as tetramers, composed of four pore-forming alpha subunits, and KV4.2 activity can be modulated by auxiliary beta subunits. Understanding KV4.2 dynamics and interactions with other proteins is important for elucidating mechanisms underlying various neurological disorders and developing targeted therapies.

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KV4.2 Antibody (H-5) References:

1. Subunit composition of Kv1 channels in human CNS.  |  Coleman, SK., et al. 1999. J Neurochem. 73: 849-58. PMID: 10428084
2. Subunit composition determines Kv1 potassium channel surface expression.  |  Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
3. Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.  |  Liu, J., et al. 2015. PLoS One. 10: e0133274. PMID: 26196737
4. Kv4.2 knockout mice display learning and memory deficits in the Lashley maze.  |  Smith, GD., et al. 2016. F1000Res. 5: 2456. PMID: 28163893
5. Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility.  |  Hu, JH., et al. 2020. Nat Commun. 11: 1567. PMID: 32218435
6. Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3.  |  Seifert, C., et al. 2020. J Biol Chem. 295: 12099-12110. PMID: 32641494
7. Voltage-dependent potassium channel Kv4.2 alleviates the ischemic stroke impairments through activating neurogenesis.  |  Xiao, F., et al. 2021. Neurochem Int. 150: 105155. PMID: 34384853
8. Identification of Kv4.2 protein complex and modifications by tandem affinity purification-mass spectrometry in primary neurons.  |  Hu, JH., et al. 2022. Front Cell Neurosci. 16: 1070305. PMID: 36568885
9. The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing.  |  Deal, KK., et al. 1994. J Neurosci. 14: 1666-76. PMID: 8126562
10. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain.  |  Veh, RW., et al. 1995. Eur J Neurosci. 7: 2189-205. PMID: 8563969
11. Beta subunits promote K+ channel surface expression through effects early in biosynthesis.  |  Shi, G., et al. 1996. Neuron. 16: 843-52. PMID: 8608002
12. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes.  |  Rhodes, KJ., et al. 1997. J Neurosci. 17: 8246-58. PMID: 9334400

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KV4.2 Antibody (H-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-KV4.2 Antibody (H-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KV4.2 Antibody (H-5) Specifications

Alternate Product Name: KV4.2

Product Clone Name: H-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 406-630

Epitope Target: KV4.2

Epitope Species: human

Product Reactivity/Detection: KV4.2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for KV4.2 Antibody (H-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p-KV4.2 antibody is p-KV4.2 Antibody (A-5): sc-377545.