KV3.1 Antibody (E-2): sc-514554
- KV3.1 Antibody (E-2) is a mouse monoclonal IgG2a κ KV3.1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 118-179 mapping within an internal region of KV3.1 of human origin
- KV3.1 Antibody (E-2) is recommended for detection of KV3.1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-KV3.1 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KV3.1 Antibody (E-2) for WB applications. These reagents are now offered in bundles with KV3.1 Antibody (E-2) (see ordering information below).
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SEE ALSO...
KV3.1 Antibody (E-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects KV3.1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KV3.1 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KV3.1, a member of the voltage-gated potassium channel family, plays a crucial role in regulating neuronal excitability and action potential repolarization, which is essential for proper nervous system functioning. Located predominantly in the central nervous system, KV3.1 channels facilitate rapid repolarization of action potentials, allowing neurons to fire at high frequencies, which is vital for processes such as signal transmission and synaptic plasticity. KV3.1 gene, mapping to chromosome 11p15, produces multiple splice variants that can influence ion permeability and channel kinetics, thereby affecting neuronal communication and overall brain function. Additionally, KV3.1 interacts with other potassium channel subtypes, such as KV3.3, to form heteromeric channels that further modulate excitability and contribute to fine-tuning neuronal signaling. This intricate interplay underscores KV3.1′s importance in maintaining the balance of excitatory and inhibitory signals in the brain, making KV3.1 a significant target for research in neurophysiology and potential therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KV3.1 Antibody (E-2) References:
- Modulation of Kv channel alpha/beta subunit interactions. | Martens, JR., et al. 1999. Trends Cardiovasc Med. 9: 253-8. PMID: 11094335
- Expression of the Kv3.1 potassium channel in the avian auditory brainstem. | Parameshwaran, S., et al. 2001. J Neurosci. 21: 485-94. PMID: 11160428
- Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. | Espinosa, F., et al. 2001. J Neurosci. 21: 6657-65. PMID: 11517255
- Differential subcellular localization of the two alternatively spliced isoforms of the Kv3.1 potassium channel subunit in brain. | Ozaita, A., et al. 2002. J Neurophysiol. 88: 394-408. PMID: 12091563
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KV3.1 Antibody (E-2) | sc-514554 | 200 µg/ml | $322.00 | |||
KV3.1 Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-531157 | 200 µg Ab; 10 µg BP | $361.00 | |||
KV3.1 Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-524766 | 200 µg Ab, 40 µg BP | $361.00 | |||
KV3.1 Antibody (E-2): m-IgG2a BP-HRP Bundle | sc-547708 | 200 µg Ab; 10 µg BP | $361.00 | |||
KV3.1 Antibody (E-2) AC | sc-514554 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KV3.1 Antibody (E-2) HRP | sc-514554 HRP | 200 µg/ml | $322.00 | |||
KV3.1 Antibody (E-2) FITC | sc-514554 FITC | 200 µg/ml | $336.00 | |||
KV3.1 Antibody (E-2) PE | sc-514554 PE | 200 µg/ml | $349.00 | |||
KV3.1 Antibody (E-2) Alexa Fluor® 488 | sc-514554 AF488 | 200 µg/ml | $364.00 | |||
KV3.1 Antibody (E-2) Alexa Fluor® 546 | sc-514554 AF546 | 200 µg/ml | $364.00 | |||
KV3.1 Antibody (E-2) Alexa Fluor® 594 | sc-514554 AF594 | 200 µg/ml | $364.00 | |||
KV3.1 Antibody (E-2) Alexa Fluor® 647 | sc-514554 AF647 | 200 µg/ml | $364.00 | |||
KV3.1 Antibody (E-2) Alexa Fluor® 680 | sc-514554 AF680 | 200 µg/ml | $364.00 | |||
KV3.1 Antibody (E-2) Alexa Fluor® 790 | sc-514554 AF790 | 200 µg/ml | $364.00 |