KSHV ORF 62 Antibody (5B7B6): sc-53949

KSHV ORF 62 Antibody (5B7B6) is a mouse monoclonal IgM antibody that detects KSHV ORF 62 protein of KSHV origin by western blotting (WB). Anti-KSHV ORF 62 antibody (5B7B6) is available as the non-conjugated format. KSHV ORF 62 plays a crucial role in the viral life cycle, particularly in the assembly of the viral capsid, where KSHV ORF 62 forms heterotrimeric complexes with ORF 26 proteins. This structural arrangement is essential for the stability and integrity of the capsid, which protects the viral genome and facilitates delivery into host cells. Understanding KSHV ORF 62 function is vital, as KSHV ORF 62 is implicated in the pathogenesis of Kaposi′s sarcoma and other lymphoproliferative disorders, especially in immunocompromised individuals. KSHV ORF 62 interaction with HIV-1 trans-activating protein (HIV-1 Tat) further underscores KSHV ORF 62′s importance in oncogenic processes, as KSHV ORF 62 may enhance the proliferation of abnormal plasma cells in conditions like myeloma. Anti-KSHV ORF 62 antibody (5B7B6) enables researchers to gain insights into the mechanisms of KSHV pathogenesis and interactions with host cellular processes.

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KSHV ORF 62 Antibody (5B7B6) References:

1. High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations.  |  Zong, JC., et al. 1999. J Virol. 73: 4156-70. PMID: 10196312
2. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus.  |  Nealon, K., et al. 2001. J Virol. 75: 2866-78. PMID: 11222712
3. Expression of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor monocistronic and bicistronic transcripts in primary effusion lymphomas.  |  Nador, RG., et al. 2001. Virology. 287: 62-70. PMID: 11504542
4. Antigenic open reading frames from HHV-8 are present in multiple myeloma patients and normal individuals at similar frequency.  |  Zhu, YX., et al. 2002. Leuk Lymphoma. 43: 369-75. PMID: 11999572
5. RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells.  |  Burnside, KL., et al. 2006. Virology. 354: 103-15. PMID: 16879850
6. Significance of variation within HIV, EBV, and KSHV subtypes.  |  Stebbing, J., et al. 2006. J Int Assoc Physicians AIDS Care (Chic). 5: 93-102. PMID: 16928877
7. Gene structure and expression of Kaposi's sarcoma-associated herpesvirus ORF56, ORF57, ORF58, and ORF59.  |  Majerciak, V., et al. 2006. J Virol. 80: 11968-81. PMID: 17020939
8. Modern evolutionary history of the human KSHV genome.  |  Hayward, GS. and Zong, JC. 2007. Curr Top Microbiol Immunol. 312: 1-42. PMID: 17089792
9. The KSHV and other human herpesviral G protein-coupled receptors.  |  Cannon, M. 2007. Curr Top Microbiol Immunol. 312: 137-56. PMID: 17089796
10. [The morphologic variants of KSHV/HHV 8-associated lymphoproliferations].  |  Loddenkemper, C., et al. 2007. Pathologe. 28: 46-9. PMID: 17160657
11. KSHV/HHV-8 and HIV infection in Kaposi's sarcoma development.  |  Pyakurel, P., et al. 2007. Infect Agent Cancer. 2: 4. PMID: 17270056
12. Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression.  |  Sadagopan, S., et al. 2007. J Virol. 81: 3949-68. PMID: 17287275

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KSHV ORF 62 Antibody (5B7B6) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KSHV ORF 62 Antibody (5B7B6) Specifications

Alternate Product Name: KSHV ORF 62

Product Clone Name: 5B7B6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: KSHV ORF 62

Epitope Species: KSHV

Product Reactivity/Detection: Kaposi′s sarcoma-associated herpes virus (KSHV) ORF 62

Species Reactivity/Detection: KSHV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KSHV ORF 62 Antibody (5B7B6): N/A