KRR1 Antibody (F-9): sc-365192

KRR1 Antibody (F-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects KRR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KRR1 (F-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KRR1, also known as HRB2 (HIV-1 Rev binding protein 2) or RIP-1 (Rev interacting protein 1), plays a vital role in the biogenesis of the small subunit processome (SSU), which is essential for ribosome assembly and pre-rRNA processing. KRR1 is composed of 381 amino acids and is evolutionarily conserved across species, including humans, yeast, flies, nematodes, and rice. KRR1 is localized in the nucleolus and is highly expressed in dividing cells, where KRR1 is crucial for rRNA maturation. A conserved KH domain in KRR1 allows RNA binding, highlighting KRR1′s importance in the regulation of ribosome biogenesis. Notably, depletion of SSU proteins, including KRR1, leads to cell cycle arrest in the G1 phase, underscoring KRR1′s critical function in cellular proliferation and growth.

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KRR1 Antibody (F-9) References:

1. Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus.  |  Sasaki, T., et al. 2000. Mol Cell Biol. 20: 7971-9. PMID: 11027267
2. The KRR1 gene encodes a protein required for 18S rRNA synthesis and 40S ribosomal subunit assembly in Saccharomyces cerevisiae.  |  Gromadka, R. and Rytka, J. 2000. Acta Biochim Pol. 47: 993-1005. PMID: 11996121
3. Functional and physical interactions of Krr1p, a Saccharomyces cerevisiae nucleolar protein.  |  Gromadka, R., et al. 2004. Acta Biochim Pol. 51: 173-87. PMID: 15094838
4. The small subunit processome is required for cell cycle progression at G1.  |  Bernstein, KA. and Baserga, SJ. 2004. Mol Biol Cell. 15: 5038-46. PMID: 15356263
5. The small-subunit processome is a ribosome assembly intermediate.  |  Bernstein, KA., et al. 2004. Eukaryot Cell. 3: 1619-26. PMID: 15590835
6. Inhibition of krr1 gene expression in Giardia canis by a virus-mediated hammerhead ribozyme.  |  Chen, L., et al. 2007. Vet Parasitol. 143: 14-20. PMID: 16982153
7. [The cleavage activity of GCV transfer vector-mediated hammerhead ribozyme for KRR1 in vitro transcript].  |  Chen, LF., et al. 2007. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 25: 279-84. PMID: 18038796

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KRR1 Antibody (F-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KRR1 Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KRR1 Antibody (F-9) Specifications

Alternate Product Name: KRR1

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 32-231

Epitope Target: KRR1

Epitope Species: human

Product Reactivity/Detection: KRR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KRR1 Antibody (F-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin