kpm Antibody (C-2): sc-515579
- kpm Antibody (C-2) is a mouse monoclonal IgG1 κ kpm antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 141-406 mapping within an internal region of kpm of human origin
- kpm Antibody (C-2) is recommended for detection of kpm of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-kpm Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for kpm Antibody (C-2) for WB and IHC(P) applications. These reagents are now offered in bundles with kpm Antibody (C-2) (see ordering information below).
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SEE ALSO...
kpm Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects kpm protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). kpm Antibody (C-2) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. kpm (C-2) antibody recognizes a member of the serine/threonine protein kinase family that plays a crucial role in regulating cell cycle progression, particularly during mitosis. kpm (C-2) monoclonal antibody targets a protein essential for maintaining proper cell division through phosphorylation of key substrates controlling cell cycle phase transitions. kpm protein expression remains consistent throughout the cell cycle, with significant phosphorylation during mitosis vital for function. Dysregulation or loss of kpm can lead to aberrant cell cycle progression and has been implicated in various human cancers, highlighting kpm′s importance as a potential therapeutic target. kpm shares highest homology with human LATS1 protein, which negatively regulates Cdc2 kinase activity during early mitosis, further emphasizing kpm′s significance in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
kpm Antibody (C-2) References:
- Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. | Hori, T., et al. 2000. Oncogene. 19: 3101-9. PMID: 10871863
- Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor. | Kamikubo, Y., et al. 2003. J Biol Chem. 278: 17609-14. PMID: 12624101
- The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. | Powzaniuk, M., et al. 2004. Mol Endocrinol. 18: 2011-23. PMID: 15131260
- Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. | McPherson, JP., et al. 2004. EMBO J. 23: 3677-88. PMID: 15343267
- cot-1, a gene required for hyphal elongation in Neurospora crassa, encodes a protein kinase. | Yarden, O., et al. 1992. EMBO J. 11: 2159-66. PMID: 1534751
- Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73. | Kawahara, M., et al. 2008. Blood. 112: 3856-66. PMID: 18565851
- The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle. | Johnston, LH., et al. 1990. Mol Cell Biol. 10: 1358-66. PMID: 2181271
- Draft Genome Sequences of the Clinical Isolates Kp 23 and KPM 20. | Maclean, AKW. and Hanson, ND. 2021. Microbiol Resour Announc. 10: PMID: 33766899
- Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. | Rojas, LA., et al. 2023. Nature. 618: 144-150. PMID: 37165196
- Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma. | Blank, CU., et al. 2024. N Engl J Med. 391: 1696-1708. PMID: 38828984
- The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. | Toyn, JH. and Johnston, LH. 1994. EMBO J. 13: 1103-13. PMID: 8131744
- Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. | Tao, W., et al. 1999. Nat Genet. 21: 177-81. PMID: 9988268
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
kpm Antibody (C-2) | sc-515579 | 200 µg/ml | $316.00 | |||
kpm Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-531425 | 200 µg Ab; 10 µg BP | $354.00 | |||
kpm Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-525113 | 200 µg Ab, 40 µg BP | $354.00 | |||
kpm Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-544547 | 200 µg Ab; 20 µg BP | $354.00 | |||
kpm Antibody (C-2) AC | sc-515579 AC | 500 µg/ml, 25% agarose | $416.00 | |||
kpm Antibody (C-2) HRP | sc-515579 HRP | 200 µg/ml | $316.00 | |||
kpm Antibody (C-2) FITC | sc-515579 FITC | 200 µg/ml | $330.00 | |||
kpm Antibody (C-2) PE | sc-515579 PE | 200 µg/ml | $343.00 | |||
kpm Antibody (C-2) Alexa Fluor® 488 | sc-515579 AF488 | 200 µg/ml | $357.00 | |||
kpm Antibody (C-2) Alexa Fluor® 546 | sc-515579 AF546 | 200 µg/ml | $357.00 | |||
kpm Antibody (C-2) Alexa Fluor® 594 | sc-515579 AF594 | 200 µg/ml | $357.00 | |||
kpm Antibody (C-2) Alexa Fluor® 647 | sc-515579 AF647 | 200 µg/ml | $357.00 | |||
kpm Antibody (C-2) Alexa Fluor® 680 | sc-515579 AF680 | 200 µg/ml | $357.00 | |||
kpm Antibody (C-2) Alexa Fluor® 790 | sc-515579 AF790 | 200 µg/ml | $357.00 |