KOR-1 Antibody (D-8): sc-374479

KOR-1 Antibody (D-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects KOR-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KOR-1 (D-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KOR-1, also known as the kappa-type opioid receptor, plays a crucial role in mediating the effects of endogenous opioid peptides and exogenous opiates, such as morphine. Located primarily in the central nervous system, KOR-1 is involved in modulating pain perception, stress response, and emotional regulation. KOR-1 activation leads to a cascade of intracellular signaling events that can inhibit neurotransmitter release, thereby influencing various brain functions. KOR-1 receptor is part of the G-protein-coupled receptor superfamily, which is characterized by seven transmembrane domains and ability to interact with G-proteins. Understanding KOR-1 structure and function is essential for developing targeted therapies for pain management and mood disorders, as well as for exploring potential roles in addiction and other neuropsychiatric conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KOR-1 Antibody (D-8) References:

1. Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.  |  Chang, KJ. and Cuatrecasas, P. 1979. J Biol Chem. 254: 2610-8. PMID: 218947
2. Mu-, delta- and kappa-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate.  |  Schoffelmeer, AN., et al. 1988. Eur J Pharmacol. 154: 169-78. PMID: 2906610
3. Mu and kappa opioids inhibit transmitter release by different mechanisms.  |  Cherubini, E. and North, RA. 1985. Proc Natl Acad Sci U S A. 82: 1860-3. PMID: 2984670
4. Identification of Dipeptidyl Peptidase (DPP) Family Genes in Clinical Breast Cancer Patients via an Integrated Bioinformatics Approach.  |  Choy, TK., et al. 2021. Diagnostics (Basel). 11: PMID: 34359286
5. Neurocircuitry basis of the opioid use disorder-post-traumatic stress disorder comorbid state: conceptual analyses using a dimensional framework.  |  Upadhyay, J., et al. 2022. Lancet Psychiatry. 9: 84-96. PMID: 34774203
6. Human leumorphin is a potent, kappa opioid receptor agonist.  |  Suda, M., et al. 1984. Neurosci Lett. 50: 49-52. PMID: 6149506
7. Molecular biology and pharmacology of cloned opioid receptors.  |  Knapp, RJ., et al. 1995. FASEB J. 9: 516-25. PMID: 7737460
8. Molecular biology of the opioid receptors: structures, functions and distributions.  |  Minami, M. and Satoh, M. 1995. Neurosci Res. 23: 121-45. PMID: 8532211
9. k-Opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release.  |  Simmons, ML. and Chavkin, C. 1996. Mol Pharmacol. 50: 80-5. PMID: 8700123
10. Molecular pharmacology of the opioid receptors.  |  Satoh, M. and Minami, M. 1995. Pharmacol Ther. 68: 343-64. PMID: 8788562
11. Molecular biology of opioid receptors: recent advances.  |  Singh, VK., et al. 1997. Neuroimmunomodulation. 4: 285-97. PMID: 9650823

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KOR-1 Antibody (D-8) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-KOR-1 Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KOR-1 Antibody (D-8) Specifications

Alternate Product Name: Kappa Opioid Receptor

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 351-380

Epitope Target: KOR-1

Epitope Species: human

Product Reactivity/Detection: KOR-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for KOR-1 Antibody (D-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin