KNP-I Antibody (E-6): sc-377328
- KNP-I Antibody (E-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 175-207 within an internal region of KNP-I of human origin
- recommended for detection of KNP-I of human origin and, to a lesser extent, D10Jhu81e of mouse origin and the corresponding rat homolog by WB, IP, IF and ELISA; also reactive with additional species, including and bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KNP-I Antibody (E-6) for WB applications. These reagents are now offered in bundles with KNP-I Antibody (E-6) (see ordering information below).
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KNP-I Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects KNP-I in human, mouse, and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KNP-I is a ubiquitously expressed mitochondrial protein belonging to the ES1 family, and its highly conserved nature across various species underscores its significant biological role. KNP-I (E-6) antibody targets a protein primarily involved in mitochondrial function, which is crucial for energy production and cellular metabolism. Mitochondria are often referred to as the powerhouses of the cell, and any dysfunction in mitochondrial proteins like KNP-I can lead to a range of metabolic disorders and contribute to the pathology of diseases such as Down syndrome, where the overproduction of the C21orf33 gene product may play a role. The gene encoding KNP-I is located on human chromosome 21, near a region associated with several genetic diseases, highlighting its potential involvement in conditions linked to chromosomal abnormalities. While KNP-I is expressed in various tissues, KNP-I shows the highest expression levels in the heart and muscle, indicating its vital role in energy-demanding tissues. Anti-KNP-I antibody (E-6) is an essential tool for researchers investigating mitochondrial function and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KNP-I Antibody (E-6) | sc-377328 | 200 µg/ml | $316.00 | |||
KNP-I Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-538037 | 200 µg Ab; 10 µg BP | $354.00 | |||
KNP-I Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-535561 | 200 µg Ab; 40 µg BP | $354.00 | |||
KNP-I Antibody (E-6): m-IgG1 BP-HRP Bundle | sc-545496 | 200 µg Ab; 20 µg BP | $354.00 | |||
KNP-I (E-6) Neutralizing Peptide | sc-377328 P | 100 µg/0.5 ml | $68.00 |