KLK7 Antibody (H-5): sc-514447

KLK7 Antibody (H-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects KLK7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-KLK7 antibody (H-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KLK7, a member of the kallikrein family, plays a significant role in regulating various physiological processes, including skin desquamation and modulation of inflammatory responses. KLK7 is primarily located in the skin and secreted into the extracellular space, where KLK7 influences keratinocyte behavior and contributes to skin homeostasis maintenance. KLK7′s location importance is underscored by involvement in skin disorders, such as atopic dermatitis and psoriasis, where dysregulation of kallikrein activity can lead to impaired barrier function and increased susceptibility to infections. The human KLK gene family consists of 15 serine proteases, and while specific functions of many members remain to be fully elucidated, KLK7′s activity is crucial for maintaining skin integrity and health.

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KLK7 Antibody (H-5) References:

1. The new human kallikrein gene family: implications in carcinogenesis.  |  Diamandis, EP., et al. 2000. Trends Endocrinol Metab. 11: 54-60. PMID: 10675891
2. Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.  |  Yousef, GM., et al. 2000. Biochem Biophys Res Commun. 276: 125-33. PMID: 11006094
3. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer.  |  Yousef, GM., et al. 2001. J Biol Chem. 276: 53-61. PMID: 11010966
4. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.  |  Clements, J., et al. 2001. Biol Chem. 382: 5-14. PMID: 11258672
5. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.  |  Yousef, GM., et al. 2001. Cancer Res. 61: 3425-31. PMID: 11309303
6. Expression of the kallikrein gene family in normal and Alzheimer's disease brain.  |  Shimizu-Okabe, C., et al. 2001. Neuroreport. 12: 2747-51. PMID: 11522960
7. Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer.  |  Dorn, J., et al. 2014. Biol Chem. 395: 95-107. PMID: 23999494
8. Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity.  |  Oliveira, JR., et al. 2015. Biochim Biophys Acta. 1854: 73-83. PMID: 25448018
9. Incomplete KLK7 Secretion and Upregulated LEKTI Expression Underlie Hyperkeratotic Stratum Corneum in Atopic Dermatitis.  |  Igawa, S., et al. 2017. J Invest Dermatol. 137: 449-456. PMID: 27769847
10. KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.  |  Kasparek, P., et al. 2017. PLoS Genet. 13: e1006566. PMID: 28095415
11. High levels of KLK7 protein expression are related to a favorable prognosis in triple-negative breast cancer patients.  |  Geng, X., et al. 2020. Am J Cancer Res. 10: 1785-1792. PMID: 32642290
12. Analysis of kallikrein-related peptidase 7 (KLK7) autolysis reveals novel protease and cytokine substrates.  |  Ghodge, SV. and Lazarus, RA. 2024. Biol Chem.. PMID: 39655764

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KLK7 Antibody (H-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KLK7 Antibody (H-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KLK7 Antibody (H-5) Specifications

Alternate Product Name: KLK7

Product Clone Name: H-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 154-203

Epitope Target: KLK7

Epitope Species: human

Product Reactivity/Detection: KLK7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KLK7 Antibody (H-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin