KLK6 Antibody (D-1): sc-374564

KLK6 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects KLK6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). KLK6 (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Kallikrein 6 (KLK6) is a member of the kallikrein family of serine proteases, which play crucial roles in various physiological processes, including tissue remodeling and inflammation. KLK6 is primarily located in the extracellular space and is secreted by various tissues, including the prostate and breast, where KLK6 is believed to be involved in the regulation of cellular processes and signaling pathways. KLK6 dysregulation has been implicated in several cancers, making KLK6 a potential biomarker for tumor progression and a target for therapeutic intervention. KLK6 is known to interact with other proteins in the kallikrein family, such as KLK2 and KLK3, which are also associated with prostate cancer diagnostics. The human KLK gene family consists of 15 serine proteases clustered on chromosome 19q13, with specific members exhibiting high expression in prostatic and pancreatic tissues. Understanding KLK6 function and interactions is essential for elucidating KLK6′s role in cancer biology and developing targeted therapies.

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KLK6 Antibody (D-1) References:

1. The new human kallikrein gene family: implications in carcinogenesis.  |  Diamandis, EP., et al. 2000. Trends Endocrinol Metab. 11: 54-60. PMID: 10675891
2. Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.  |  Yousef, GM., et al. 2000. Biochem Biophys Res Commun. 276: 125-33. PMID: 11006094
3. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer.  |  Yousef, GM., et al. 2001. J Biol Chem. 276: 53-61. PMID: 11010966
4. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.  |  Clements, J., et al. 2001. Biol Chem. 382: 5-14. PMID: 11258672
5. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.  |  Yousef, GM., et al. 2001. Cancer Res. 61: 3425-31. PMID: 11309303
6. Expression of the kallikrein gene family in normal and Alzheimer's disease brain.  |  Shimizu-Okabe, C., et al. 2001. Neuroreport. 12: 2747-51. PMID: 11522960
7. KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes.  |  Sidiropoulos, KG., et al. 2016. Mol Oncol. 10: 993-1007. PMID: 27093921
8. KLK6 protease accelerates skin tumor formation and progression.  |  Khoury, N., et al. 2018. Carcinogenesis. 39: 1529-1536. PMID: 30137206
9. KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.  |  Billi, AC., et al. 2020. J Clin Invest. 130: 3151-3157. PMID: 32155135
10. KLK6 mediates stemness and metabolism of gastric carcinoma cells via the PI3K/AKT/mTOR signaling pathway.  |  Zhou, D., et al. 2021. Oncol Lett. 22: 824. PMID: 34691251
11. KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma.  |  Zhao, K., et al. 2022. Dis Markers. 2022: 3373851. PMID: 36193495
12. KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages.  |  Hwang, YS., et al. 2022. Cells. 11: PMID: 36552865

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KLK6 Antibody (D-1) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-KLK6 Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KLK6 Antibody (D-1) Specifications

Alternate Product Name: KLK6

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 111-170

Epitope Target: KLK6

Epitope Species: human

Product Reactivity/Detection: KLK6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for KLK6 Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin