KLF15 Antibody (A-5): sc-271675
- KLF15 Antibody (A-5) is a mouse monoclonal IgG2a κ KLF15 antibody, cited in 15 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-23 at the N-terminus of KLF15 of human origin
- KLF15 Antibody (A-5) is recommended for detection of KLF15 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-KLF15 Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-271675 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KLF15 Antibody (A-5) for WB and IHC(P) applications. These reagents are now offered in bundles with KLF15 Antibody (A-5) (see ordering information below).
KLF15 Antibody (A-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects KLF15 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-KLF15 antibody (A-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KLF15, a member of the Krüppel-like factor family, is a crucial transcriptional regulator primarily expressed in the liver, heart, skeletal muscle, and kidney, where KLF15 plays a significant role in metabolic processes. Notably, KLF15 is essential for the regulation of glucose transporter type 4 (GLUT4), which is vital for glucose uptake in adipose and muscle tissues, thereby influencing insulin sensitivity and energy homeostasis. Nuclear localization of KLF15 is critical for function, as nuclear presence allows KLF15 to interact with specific DNA sequences in the promoters of target genes, facilitating transcriptional activation necessary for metabolic regulation. Understanding KLF15′s role in these tissues is important for elucidating potential implications in metabolic disorders, such as obesity and diabetes, making anti-KLF15 antibody (A-5) a valuable tool for researchers studying these conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KLF15 Antibody (A-5) References:
- The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. | Gray, S., et al. 2002. J Biol Chem. 277: 34322-8. PMID: 12097321
- Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters. | Otteson, DC., et al. 2004. Invest Ophthalmol Vis Sci. 45: 2522-30. PMID: 15277472
- Role of Krüppel-like factor 15 in PEPCK gene expression in the liver. | Teshigawara, K., et al. 2005. Biochem Biophys Res Commun. 327: 920-6. PMID: 15649433
- Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. | Mori, T., et al. 2005. J Biol Chem. 280: 12867-75. PMID: 15664998
- Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements. | Otteson, DC., et al. 2005. BMC Mol Biol. 6: 15. PMID: 15963234
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLF15 Antibody (A-5) | sc-271675 | 200 µg/ml | $322.00 | |||
KLF15 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-529239 | 200 µg Ab; 10 µg BP | $361.00 | |||
KLF15 Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-522020 | 200 µg Ab, 40 µg BP | $361.00 | |||
KLF15 Antibody (A-5): m-IgG2a BP-HRP Bundle | sc-547283 | 200 µg Ab; 10 µg BP | $361.00 | |||
KLF15 Antibody (A-5) X | sc-271675 X | 200 µg/0.1 ml | $322.00 | |||
KLF15 Antibody (A-5) AC | sc-271675 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KLF15 Antibody (A-5) HRP | sc-271675 HRP | 200 µg/ml | $322.00 | |||
KLF15 Antibody (A-5) FITC | sc-271675 FITC | 200 µg/ml | $336.00 | |||
KLF15 Antibody (A-5) PE | sc-271675 PE | 200 µg/ml | $349.00 | |||
KLF15 Antibody (A-5) Alexa Fluor® 488 | sc-271675 AF488 | 200 µg/ml | $364.00 | |||
KLF15 Antibody (A-5) Alexa Fluor® 546 | sc-271675 AF546 | 200 µg/ml | $364.00 | |||
KLF15 Antibody (A-5) Alexa Fluor® 594 | sc-271675 AF594 | 200 µg/ml | $364.00 | |||
KLF15 Antibody (A-5) Alexa Fluor® 647 | sc-271675 AF647 | 200 µg/ml | $364.00 | |||
KLF15 Antibody (A-5) Alexa Fluor® 680 | sc-271675 AF680 | 200 µg/ml | $364.00 | |||
KLF15 Antibody (A-5) Alexa Fluor® 790 | sc-271675 AF790 | 200 µg/ml | $364.00 | |||
KLF15 (A-5) Neutralizing Peptide | sc-271675 P | 100 µg/0.5 ml | $69.00 |