KIR4.2 Antibody (G-5): sc-376322
- KIR4.2 Antibody (G-5) is a mouse monoclonal IgG2a κ KIR4.2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 304-375 mapping at the C-terminus of KIR4.2 of human origin
- KIR4.2 Antibody (G-5) is recommended for detection of KIR4.2 of human origin by WB, IP, IF and ELISA
- Anti-KIR4.2 Antibody (G-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of KIR4.2 (G-5): sc-376322.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for KIR4.2 Antibody (G-5) for WB applications. These reagents are now offered in bundles with KIR4.2 Antibody (G-5) (see ordering information below).
KIR4.2 Antibody (G-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects KIR4.2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KIR4.2 monoclonal antibody (G-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIR4.2, also known as KCNJ15, is a member of the inwardly rectifying potassium channel family, which is essential for maintaining the resting membrane potential and regulating potassium ion flow into cells. This function is particularly important in excitable tissues, such as the brain and heart, where precise ion balance is crucial for normal physiological activity. KIR4.2 is expressed in various human tissues, including the kidney, lung, heart, thymus, and thyroid during development, and KIR4.2′s gene is located on chromosome 21, which is significant in the context of Down syndrome, as alterations in expression may contribute to the pathogenesis of this condition. Additionally, KIR4.2 interacts with other potassium channels, such as Kir5.1, to form functional channels in the kidney and pancreas, highlighting KIR4.2′s role in cellular ion homeostasis and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KIR4.2 Antibody (G-5) References:
- Developmentally regulated expression of the murine ortholog of the potassium channel KIR4.2 (KCNJ15). | Thiery, E., et al. 2000. Mech Dev. 95: 313-6. PMID: 10906485
- The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. | Liu, Y., et al. 2000. Cytogenet Cell Genet. 90: 60-3. PMID: 11060447
- Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes. | Li, L., et al. 2001. Glia. 33: 57-71. PMID: 11169792
- Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1. | Pessia, M., et al. 2001. J Physiol. 532: 359-67. PMID: 11306656
- Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. | Neusch, C., et al. 2001. J Neurosci. 21: 5429-38. PMID: 11466414
- Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). | Shuck, ME., et al. 1997. J Biol Chem. 272: 586-93. PMID: 8995301
- Inwardly rectifying potassium channels: their molecular heterogeneity and function. | Isomoto, S., et al. 1997. Jpn J Physiol. 47: 11-39. PMID: 9159640
- A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). | Gosset, P., et al. 1997. Genomics. 44: 237-41. PMID: 9299242
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIR4.2 Antibody (G-5) | sc-376322 | 200 µg/ml | $316.00 | |||
KIR4.2 Antibody (G-5): m-IgG Fc BP-HRP Bundle | sc-526023 | 200 µg Ab; 10 µg BP | $354.00 | |||
KIR4.2 Antibody (G-5): m-IgG2a BP-HRP Bundle | sc-546486 | 200 µg Ab; 10 µg BP | $354.00 | |||
KIR4.2 Antibody (G-5) AC | sc-376322 AC | 500 µg/ml, 25% agarose | $416.00 | |||
KIR4.2 Antibody (G-5) HRP | sc-376322 HRP | 200 µg/ml | $316.00 | |||
KIR4.2 Antibody (G-5) FITC | sc-376322 FITC | 200 µg/ml | $330.00 | |||
KIR4.2 Antibody (G-5) PE | sc-376322 PE | 200 µg/ml | $343.00 | |||
KIR4.2 Antibody (G-5) Alexa Fluor® 488 | sc-376322 AF488 | 200 µg/ml | $357.00 | |||
KIR4.2 Antibody (G-5) Alexa Fluor® 546 | sc-376322 AF546 | 200 µg/ml | $357.00 | |||
KIR4.2 Antibody (G-5) Alexa Fluor® 594 | sc-376322 AF594 | 200 µg/ml | $357.00 | |||
KIR4.2 Antibody (G-5) Alexa Fluor® 647 | sc-376322 AF647 | 200 µg/ml | $357.00 | |||
KIR4.2 Antibody (G-5) Alexa Fluor® 680 | sc-376322 AF680 | 200 µg/ml | $357.00 | |||
KIR4.2 Antibody (G-5) Alexa Fluor® 790 | sc-376322 AF790 | 200 µg/ml | $357.00 |