KIR4.1 Antibody (1C11): sc-293252

KIR4.1 Antibody (1C11) is a mouse monoclonal IgG2a kappa light chain antibody that detects KIR4.1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KIR4.1 antibody (1C11) is available as the non-conjugated format. KIR4.1 protein, also known as Kir1.2, plays a critical role in maintaining potassium ion homeostasis within the central nervous system, as KIR4.1 is predominantly expressed in glial cells, astrocytes, and cortical neurons. This inwardly rectifying potassium channel facilitates the influx of potassium ions, which is essential for regulating neuronal excitability and supporting myelination in the developing nervous system. Proper functioning of KIR4.1 is vital for the health of neural tissues, as disruptions in potassium ion flow can lead to neurological disorders. Additionally, KIR4.1 is expressed in myelin-synthesizing oligodendrocytes, highlighting KIR4.1′s importance in the formation and maintenance of myelin sheaths that insulate nerve fibers. The gene encoding human KIR4.1 is located on chromosome 1, and KIR4.1′s interactions with other potassium channels, such as KIR4.2 and KIR5.1, further underscore KIR4.1′s significance in cellular signaling and overall brain function.

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KIR4.1 Antibody (1C11) References:

1. Developmentally regulated expression of the murine ortholog of the potassium channel KIR4.2 (KCNJ15).  |  Thiery, E., et al. 2000. Mech Dev. 95: 313-6. PMID: 10906485
2. The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.  |  Liu, Y., et al. 2000. Cytogenet Cell Genet. 90: 60-3. PMID: 11060447
3. Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes.  |  Li, L., et al. 2001. Glia. 33: 57-71. PMID: 11169792
4. Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.  |  Pessia, M., et al. 2001. J Physiol. 532: 359-67. PMID: 11306656
5. Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination.  |  Neusch, C., et al. 2001. J Neurosci. 21: 5429-38. PMID: 11466414
6. Inwardly Rectifying Potassium Channel Kir4.1 as a Novel Modulator of BDNF Expression in Astrocytes.  |  Ohno, Y., et al. 2018. Int J Mol Sci. 19: PMID: 30356026
7. Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases.  |  Ohno, Y., et al. 2021. Int J Mol Sci. 22: PMID: 34638578
8. Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.  |  Altas, B., et al. 2024. J Cell Biol. 223: PMID: 38032389
9. Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses.  |  Zhou, X., et al. 2024. Nat Chem Biol. 20: 857-866. PMID: 38355723
10. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).  |  Shuck, ME., et al. 1997. J Biol Chem. 272: 586-93. PMID: 8995301
11. Inwardly rectifying potassium channels: their molecular heterogeneity and function.  |  Isomoto, S., et al. 1997. Jpn J Physiol. 47: 11-39. PMID: 9159640
12. A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1).  |  Gosset, P., et al. 1997. Genomics. 44: 237-41. PMID: 9299242

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIR4.1 Antibody (1C11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-KIR4.1 Antibody (1C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIR4.1 Antibody (1C11) Specifications

Alternate Product Name: KIR4.1

Product Clone Name: 1C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 276-379

Epitope Target: KIR4.1

Epitope Species: human

Product Reactivity/Detection: KIR4.1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for KIR4.1 Antibody (1C11): N/A